Review Article
Successfully Improving Ocular Drug Delivery Using the Cationic Nanoemulsion, Novasorb
Table 8
Listing of proof-of-concept and regulatory pharmacokinetics studies performed in order to test Novasorb technology in humans.
| Nonclinical studies type | Studies for Novasorb alone and Novasorb loaded |
| Proof-of-concept | (i) Ex vivo measurement of contact angle and surface tension of cationic emulsions on rabbit eyes | (ii) Evaluation and comparison of the wound healing potential of the cationic emulsion versus artificial tears in a rabbit model of corneal abrasion | (iii) Evaluation of the efficacy of a 0.1% cyclosporine A cationic emulsion in the management of keratoconjunctivitis sicca in the dog | (iv) Evaluation of the efficacy of a cationic emulsion of 0.005% latanoprost at reducing elevated intraocular pressure in glaucomatous monkeys | (v) In vitro and in vivo evaluation of a preservative-free cationic emulsion of latanoprost in corneal wound healing models |
| Regulatory pharmacokinetics studies | (i) Single and multiple doses pharmacokinetic | (ii) Systemic exposure determination and toxicokinetics following repeated instillations of BAK and CKC-containing cyclosporine A cationic emulsion |
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