A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs

Table 1

Drug formulation properties. The encapsulation retention percentage, crosslinking retention percentage, and particle sizes are shown for eleven compounds tested for loading within the polymer micelle.

Drug	Log 𝑃	Encapsulation retention (%)	Crosslinking retention (%)	Particle size (nm)
5-Fluorouracil	−0.58	0	NA	ND
Caffeine	−0.24	0	NA	ND
Melphalan	−0.22	0	NA	ND
Gemcitabine	0.14	0	NA	ND
Etoposide	0.73	12	NA	ND
Doxorubicin	1.41	80	63	30
Daunorubicin	1.68	85	78	30
BB4007431	1.94	79	90	55
Paclitaxel	3.2	93	60	36
NX-8	4.18	86	52	86
Vinorelbine	4.39	87	37	47

NA: not applicable, ND: not determined.