Review Article

Liposomal Doxorubicin in the Treatment of Breast Cancer Patients: A Review

Table 1

Comparison of AUC and in various tissues in dogs following the administration of TLC D-99 and conventional doxorubicin. Single dose 1.5 mg/kg (30 mg · m−2), IV [18].

TissuesTLC D-99Doxorubicin Ratio of   
(TLC D-99/Dox)
(uM eq-h) (h) (uM eq-h) (h)

Liver53979377971.42
Spleen5,08792559529.07
Bone marrow1,91386392754.86
Lymph nodes896211*653196*1.38
Myocardium (left ventricle)20859313500.66
Myocardium (right ventricle)18962282540.67

Due to short sampling intervals relating to apparent , these values are estimated. TLC D-99: nonpegylated liposomal doxorubicin.