Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma

Table 4

Effect of drug loading on PS and PI of OCM-CSNs.

OCMCS : CaCl2 weight ratio	PS of drug loaded NPs  (nm)	PI	PS of blank NPs (nm)
6 : 1	212.4±0.79	0.244±0.016	174.0±1.29
5 : 1	325.1±5.31	0.384±0.008	296.0±6.85
4 : 1	500.4±11.88	0.444±0.028	481.8±14.88

Values are expressed as mean ± standard deviation, 𝑛=3.
OCM-CS: 6-𝑂-carboxymethyl chitosan; CaCl₂: calcium chloride; PS: particle size; NPs: nanoparticles; PI: polydispersity index; OCM-CSNs: 6-𝑂-carboxymethyl chitosan nanoparticles.