Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma

Table 9

Effect of drug loading on CS : TPP weight ratio of 6 : 1.

DRZ loading (%)	PS (nm)	PI	Zeta potential (mV)	EE of CSNs
Blank CSNs	247.5±3.379	0.259±0.009	27.58±0.42	—
25%	249.5±3.866	0.267±0.005	+28.61±0.92	17.83±0.61
50%	250.3±2.627	0.313±0.009	+33.47±0.72	20.28±0.48
75%	244.4±1.735	0.323±0.040	+33.89±0.55	19.81±0.37

Values are expressed as mean ± standard deviation, 𝑛=3.
CS: chitosan; TPP: tripolyphosphate; PS: particle size; NPs: nanoparticles; PI: polydispersity index; EE: entrapment efficiency; CSNs: chitosan nanoparticles; DRZ: dorzolamide hydrochloride.