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Journal of Drug Delivery
Volume 2013, Article ID 803585, 8 pages
http://dx.doi.org/10.1155/2013/803585
Research Article

Infuence of Microstructure in Drug Release Behavior of Silica Nanocapsules

1Laboratorio de Materiales, Departamento de Ingeniería de Materiales y Nanotecnología, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas 20632, Venezuela
2Laboratorio de Fotoquímica, Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC), Apartado 20632, Caracas 1020, Venezuela

Received 2 May 2013; Accepted 14 June 2013

Academic Editor: Ali Nokhodchi

Copyright © 2013 Gema Gonzalez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Meso- and nanoporous structures are adequate matrices for controlled drug delivery systems, due to their large surface areas and to their bioactive and biocompatibility properties. Mesoporous materials of type SBA-15, synthesized under different pH conditions, and zeolite beta were studied in order to compare the different intrinsic morphological characteristics as pore size, pore connectivity, and pore geometry on the drug loading and release process. These materials were characterized by X-ray diffraction, nitrogen adsorption, scanning and transmission electron microscopy, and calorimetric measurements. Ibuprofen (IBU) was chosen as a model drug for the formulation of controlled-release dosage forms; it was impregnated into these two types of materials by a soaking procedure during different periods. Drug loading and release studies were followed by UV-Vis spectrophotometry. All nano- and mesostructured materials showed a similar loading behavior. It was found that the pore size and Al content strongly influenced the release process. These results suggest that the framework structure and architecture affect the drug adsorption and release properties of these materials. Both materials offer a good potential for a controlled delivery system of ibuprofen.