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Journal of Drug Delivery
Volume 2014 (2014), Article ID 575969, 6 pages
Review Article

Carboxymethyl Cellulose Acetate Butyrate: A Review of the Preparations, Properties, and Applications

Cellulose and Paper Department, National Research Center, Dokki, Cairo 12622, Egypt

Received 12 September 2014; Revised 31 October 2014; Accepted 20 November 2014; Published 4 December 2014

Academic Editor: Rosario Pignatello

Copyright © 2014 Mohamed El-Sakhawy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Carboxymethyl cellulose acetate butyrate (CMCAB) has gained increasing importance in several fields, particularly in coating technologies and pharmaceutical research. CMCAB is synthesized by esterification of CMC sodium salt with acetic and butyric anhydrides. CMCAB mixed esters are relatively high molecular weight (MW) thermoplastic polymers with high glass transition temperatures (Tg). CMCAB ester is dispersible in water and soluble in a wide range of organic solvents, allowing varied opportunity to the solvent choice. It makes application of coatings more consistent and defect-free. Its ability to slow down the release rate of highly water-soluble compounds and to increase the dissolution of poorly soluble compounds makes CMCAB a unique and potentially valuable tool in pharmaceutical and amorphous solid dispersions (ASD) formulations.