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Journal of Drug Delivery
Volume 2014, Article ID 583612, 11 pages
http://dx.doi.org/10.1155/2014/583612
Review Article

Interpenetrating Polymer Networks as Innovative Drug Delivery Systems

School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244102, India

Received 10 January 2014; Accepted 27 March 2014; Published 14 May 2014

Academic Editor: Sven Frøkjær

Copyright © 2014 Alka Lohani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. N. V. R. Kumar and N. Kumar, “Polymeric controlled drug-delivery systems: perspective issues and opportunities,” Drug Development and Industrial Pharmacy, vol. 27, no. 1, pp. 1–30, 2001. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Blume and G. Cevc, “Liposomes for the sustained drug release in vivo,” Biochimica et Biophysica Acta, vol. 1029, no. 1, pp. 91–97, 1990. View at Publisher · View at Google Scholar · View at Scopus
  3. W. B. Liechty, D. R. Kryscio, B. V. Slaughter, and N. A. Peppas, “Polymers for drug delivery systems,” Annual Review of Chemical and Biomolecular Engineering, vol. 1, pp. 149–173, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Giusti, L. Lazzeri, and M. G. Cascone, “Bioartificial materials,” in The Polymeric Materials Encyclopedia, J. C. Salomone, Ed., pp. 538–549, CRC Press, Boca Raton, Fla, USA, 1996. View at Google Scholar
  5. M. G. Cascone, “Dynamic-mechanical properties of bioartificial polymeric materials,” Polymer International, vol. 43, no. 1, pp. 55–69, 1997. View at Google Scholar · View at Scopus
  6. L. H. Sperling and R. Hu, “Interpenetrating polymer networks,” in Polymer Blends Handbook, L. A. Utracki, Ed., pp. 417–447, Springer, Dordrecht, The Netherlands, 2003. View at Google Scholar
  7. L. Ignat and A. Stanciu, “Advanced polymers: interpenetrating polymer networks,” in Handbook of Polymer Blends and Composites, A. K. Kulshreshtha and C. Vasile, Eds., vol. 3, pp. 275–280, Rapra Technology, 2003. View at Google Scholar
  8. V. Kudela, “Hydrogels,” in Encyclopedia of Polymer Science and Engineering, J. I. Kroschwitz, Ed., pp. 783–807, Wiley, New York, NY, USA, 1987. View at Google Scholar
  9. W. J. Work, K. Horie, M. Hess, and R. F. T. Stepto, “Definitions of terms related to polymer blends, composites, and multiphase polymeric materials,” Pure and Applied Chemistry, vol. 76, no. 11, pp. 1985–2007, 2004. View at Google Scholar · View at Scopus
  10. J. W. Aylsworth, “Plastic composition,” US Patent 1111284, September 1914.
  11. J. R. Millar, “Interpenetrating polymer networks, styrene-divinyl benzene copolymer with two and three interpenetrating networks and their sulphonates,” Journal of the Chemical Society, pp. 1311–1319, 1960. View at Google Scholar
  12. S. Murugesh and B. K. Mandal, “A review on interpenetrating polymer network,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 4, pp. 1–7, 2012. View at Google Scholar
  13. Y. S. Lipatov and T. T. Alekseeva, “Phase-separated interpenetrating polymer networks,” Advances in Polymer Science, vol. 208, no. 1, pp. 1–227, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. L. Zhang, L. Wang, B. Guo, and P. X. Ma, “Cytocompatible injectable carboxymethyl chitosan/N-isopropylacrylamide hydrogels for localized drug delivery,” Carbohydrate Polymers, vol. 103, pp. 110–118, 2014. View at Google Scholar
  15. S. Kaity, J. Isaac, and A. Ghosh, “Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery,” Carbohydrate Polymers, vol. 15, pp. 456–467, 2013. View at Google Scholar
  16. Q. Xu, W. Huang, L. Jiang, Z. Lei, X. Li, and H. Deng, “KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release,” Carbohydrate Polymers, vol. 97, pp. 565–570, 2013. View at Publisher · View at Google Scholar
  17. S. S. Bhattacharya, A. K. Ghosh, S. Banerjee, P. Chattopadhyay, and A. Ghosh, “Al3+ ion cross-linked interpenetrating polymeric network microbeads from tailored natural polysaccharides,” International Journal of Biological Macromolecules, vol. 51, pp. 1173–1184, 2012. View at Publisher · View at Google Scholar
  18. S. Banerjee, A. Tiwari, S. K. Yadav, S. S. Bhattacharya, A. V. Dagaji, and P. Mondal, “Influence on variation in process parameters for the design of xanthan-gum-facilitated ethyl cellulose microparticles for intestinal specific delivery,” Science and Engineering of Composite Materials, vol. 20, no. 1, pp. 23–33, 2013. View at Google Scholar
  19. K. Kumari and P. P. Kundu, “Studies on in vitro release of CPM from semi-interpenetrating polymer network (IPN) composed of chitosan and glutamic acid,” Bulletin of Materials Science, vol. 31, no. 2, pp. 159–167, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. P. V. Kulkarni and J. Keshavayya, “Chitosan-sodium alginate biodegradable interpenetrating polymer network (IPN) beads for delivery ofofloxacin hydrochloride,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 2, no. 2, pp. 77–82, 2010. View at Google Scholar · View at Scopus
  21. R. Boppana, R. V. Kulkarni, S. S. Mutalik, C. M. Setty, and B. Sa, “Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug,” Journal of Microencapsulation, vol. 27, no. 4, pp. 337–344, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Gupta, A. Siddiqui, M. Datta, and D. Ramchand, “Interpenetrating polymeric network hydrogel for stomach-specific drug delivery of clarithromycin: preparation and evaluation,” Asian Journal of Pharmaceutics, vol. 4, no. 4, pp. 179–184, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Malakar, A. K. Nayak, and D. Pal, “Development of cloxacillin loaded multiple-unit alginate-based floating system by emulsion-gelation method,” International Journal of Biological Macromolecules, vol. 50, no. 1, pp. 138–147, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Nochos, D. Douroumis, and N. Bouropoulos, “In vitro release of bovine serum albumin from alginate/HPMC hydrogel beads,” Carbohydrate Polymers, vol. 74, no. 3, pp. 451–457, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. K. H. Leong, L. Y. Chung, M. I. Noordin, Y. Onuki, M. Morishita, and K. Takayama, “Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery,” Carbohydrate Polymers, vol. 86, no. 2, pp. 555–565, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. K. S. V. Krishna Rao, B. Vijaya Kumar Naidu, M. C. S. Subha, M. Sairam, and T. M. Aminabhavi, “Novel chitosan-based pH-sensitive interpenetrating network microgels for the controlled release of cefadroxil,” Carbohydrate Polymers, vol. 66, no. 3, pp. 333–344, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. V. Bhardwaj and S. Kumar, “Design and characterization of novel interpenetrating polymer network mucoadhesive microspheres of locust bean gum and PVA for controlled release of metformin HCl,” Internationale Pharmaceutica Sciencia, vol. 2, no. 2, pp. 115–121, 2012. View at Google Scholar
  28. R. V. Kulkarni, V. Sreedhar, S. Mutalik, C. M. Setty, and B. Sa, “Interpenetrating network hydrogel membranes of sodium alginate and poly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin,” International Journal of Biological Macromolecules, vol. 47, no. 4, pp. 520–527, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Sinha, R. M. Banik, C. Haldar, and P. Maiti, “Development of ciprofloxacin hydrochloride loaded poly(ethylene glycol)/chitosan scaffold as wound dressing,” Journal of Porous Materials, vol. 20, pp. 799–807, 2013. View at Google Scholar
  30. L. V. Karabanova, S. V. Mikhalovsky, A. W. Lloyd et al., “Gradient semi-interpenetrating polymer networks based on polyurethane and poly(vinyl pyrrolidone),” Journal of Materials Chemistry, vol. 15, no. 4, pp. 499–507, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. J. D. Kosmala, D. B. Henthorn, and L. Brannon-Peppas, “Preparation of interpenetrating networks of gelatin and dextran as degradable biomaterials,” Biomaterials, vol. 21, no. 20, pp. 2019–2023, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. S. S. Bhattacharya, S. Shukla, S. Banerjee, P. Chowdhury, P. Chakrabortyc, and A. Ghosh, “Tailored IPN hydrogel bead of sodium carboxymethyl cellulose and sodium carboxymethyl xanthan gum for controlled delivery of diclofenac sodium,” Polymer-Plastics Technology and Engineering, vol. 52, pp. 795–805, 2013. View at Google Scholar
  33. S. Banerjee, G. Chaurasia, D. Pal, A. K. Ghosh, A. Ghosh, and S. Kaity, “Investigation on crosslinking density for development of novel interpenetrating polymer network (IPN) based formulation,” Journal of Scientific and Industrial Research, vol. 69, no. 10, pp. 777–784, 2010. View at Google Scholar · View at Scopus
  34. K. Landfester, “Synthesis of colloidal particles in miniemulsions,” Annual Review of Materials Research, vol. 36, pp. 231–279, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. V. Koul, R. Mohamed, D. Kuckling, H.-J. P. Adler, and V. Choudhary, “Interpenetrating polymer network (IPN) nanogels based on gelatin and poly(acrylic acid) by inverse miniemulsion technique: synthesis and characterization,” Colloids and Surfaces B, vol. 83, no. 2, pp. 204–213, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Pal, A. K. Banthia, and D. K. Majumdar, “Polymeric hydrogels: characterization and biomedical applications,” Designed Monomers and Polymers, vol. 12, no. 3, pp. 197–220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. H. Gehrke and P. I. Lee, “Hydrogels for drug delivery systems,” in Specialized Drug Delivery Systems, P. Tyle, Ed., pp. 333–392, Marcel Dekker, 1990. View at Google Scholar
  38. J. W. Dorpema, “Risk assessment of medical devices: evaluation of microbiological and toxicological safety,” Radiation Physics and Chemistry, vol. 46, no. 4-6 I, pp. 605–609, 1995. View at Publisher · View at Google Scholar · View at Scopus
  39. P. D. Nair, “Currently practised sterilization methods - some inadvertent consequences,” Journal of Biomaterials Applications, vol. 10, no. 2, pp. 121–135, 1995. View at Google Scholar · View at Scopus
  40. K. J. L. Burg and S. W. Shalaby, “Radiation sterilization of medical devices and pharmaceuticals,” ACS Symposium Series, vol. 620, pp. 240–245, 1996. View at Google Scholar · View at Scopus
  41. M. Changez, V. Koul, B. Krishna, A. K. Dinda, and V. Choudhary, “Studies on biodegradation and release of gentamicin sulphate from interpenetrating network hydrogels based on poly(acrylic acid) and gelatin: in vitro and in vivo,” Biomaterials, vol. 25, no. 1, pp. 139–146, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. M. Changez, V. Koul, and A. K. Dinda, “Efficacy of antibiotics-loaded interpenetrating network (IPNs) hydrogel based on poly(acrylic acid) and gelatin for treatment of experimental osteomyelitis: in vivo study,” Biomaterials, vol. 26, no. 14, pp. 2095–2104, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. R. V. Kulkarni, R. Boppana, G. Krishna Mohan, S. Mutalik, and N. V. Kalyane, “PH-responsive interpenetrating network hydrogel beads of poly(acrylamide)-g-carrageenan and sodium alginate for intestinal targeted drug delivery: synthesis, in vitro and in vivo evaluation,” Journal of Colloid and Interface Science, vol. 367, no. 1, pp. 509–517, 2012. View at Publisher · View at Google Scholar · View at Scopus
  44. N. A. Peppas, P. Bures, W. Leobandung, and H. Ichikawa, “Hydrogels in pharmaceutical formulations,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 1, pp. 27–46, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Ray, S. Maity, S. Mandal, T. K. Chatterjee, and B. Sa, “Studies on the release of ibuprofen from Al3+ ion cross-linked homopolymeric and interpenetrating network hydrogel beads of carboxymethyl xanthan and sodium alginate,” Advances in Polymer Technology, vol. 30, no. 1, pp. 1–11, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. L. Pescosolido, T. Vermonden, J. Malda et al., “In situ forming IPN hydrogels of calcium alginate and dextran-HEMA for biomedical applications,” Acta Biomaterialia, vol. 7, no. 4, pp. 1627–1633, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. A. Lohani and P. C. Gangwar, “Mucoadhesion: a novel approach to increase gastroretention,” Chronicles of Young Scientist, vol. 3, pp. 121–128, 2012. View at Google Scholar
  48. S. S. Bhattacharya, F. Mazahir, S. Banerjee, A. Verma, and A. Ghosh, “Preparation and in vitro evaluation of xanthan gum facilitated superabsorbent polymeric microspheres,” Carbohydrate Polymers, vol. 1, pp. 64–72, 2013. View at Google Scholar
  49. E. C. Sekhar, K. S. V. Rao, and R. R. Raju, “Chitosan/guargum-g-acrylamide semi IPN microspheres for controlled release studies of 5-Fluorouracil,” Journal of Applied Pharmaceutical Science, vol. 8, p. 199, 2012. View at Google Scholar
  50. K. J. Gandhi, S. V. Deshmane, and K. R. Biyani, “Polymers in pharmaceutical drug delivery system: a review,” International Journal of Pharmaceutical Sciences Review and Research, vol. 14, pp. 57–66, 2012. View at Google Scholar
  51. K. S. V. Krishna Rao, P. Ramasubba Reddy, Y.-I. Lee, and C. Kim, “Synthesis and characterization of chitosan-PEG-Ag nanocomposites for antimicrobial application,” Carbohydrate Polymers, vol. 87, no. 1, pp. 920–925, 2012. View at Publisher · View at Google Scholar · View at Scopus
  52. T. Cai, P. D. Hu, M. Sun et al., “Novel thermogelling dispersions of polymer nanoparticles for controlled protein release,” Nanomedicine: Nanotechnology, Biology, and Medicine, 2012. View at Publisher · View at Google Scholar · View at Scopus
  53. S. Mandal, S. K. Basu, and B. Sa, “Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride,” Carbohydrate Polymers, vol. 82, no. 3, pp. 867–873, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. R. V. Kulkarni, V. V. Baraskar, V. V. Alange, A. A. Naikawadi, and B. Sa, “Controlled release of an antihypertensive drug through interpenetrating polymer network hydrogel tablets of tamarind seed polysaccharide and sodium alginate,” Journal of Macromolecular Science, Part B, vol. 52, no. 11, pp. 1636–1650, 2013. View at Publisher · View at Google Scholar
  55. P. K. Dutta, J. Duta, and V. S. Tripathi, “Chitin and Chitosan: chemistry, properties and applications,” Journal of Scientific and Industrial Research, vol. 63, no. 1, pp. 20–31, 2004. View at Google Scholar · View at Scopus
  56. M. Rani, A. Agarwal, and Y. Negi, “Characterization and biodegradation studies for interpenetrating polymeric network (IPN) of chitosan-amino acid beads,” Journal of Biomaterials and Nanobiotechnology, vol. 2, pp. 71–84, 2011. View at Google Scholar
  57. J. Reddy, B. Nagashubha, M. Reddy, A. Moin, and H. G. Shivakumar, “Novel interpenetrating polymer matrix network microparticles for intestinal drug delivery,” Current Drug Delivery, vol. 11, no. 2, pp. 191–199, 2013. View at Google Scholar
  58. S. K. Bajpai and T. Pradeep, “Studies on equilibrium moisture absorption of kappa carrageenan,” International Food Research Journal, vol. 20, no. 5, pp. 2183–2191, 2013. View at Google Scholar
  59. J. Necas, L. Bartosikova, P. Brauner, and J. Kolar, “Hyaluronic acid (hyaluronan): a review,” Veterinarni Medicina, vol. 53, no. 8, pp. 397–411, 2008. View at Google Scholar · View at Scopus
  60. Z. Mohamadnia, M. J. Zohuriaan-Mehr, K. Kabiri, A. Jamshidi, and H. Mobedi, “pH-sensitive IPN hydrogel beads of carrageenan-alginate for controlled drug delivery,” Journal of Bioactive and Compatible Polymers, vol. 22, no. 3, pp. 342–356, 2007. View at Publisher · View at Google Scholar · View at Scopus
  61. K. I. Draget, O. Smidsrod, and G. Skjak-Braek, “Alginates from algae,” in Biopolymers, S. De Baets, E. J. Vandamme, and A. Steinbüchel, Eds., vol. 6, pp. 215–244, Wiley-VCH, Weinheim, Germany, 2002. View at Google Scholar
  62. B. M. Swamy, J. H. Chang, H. Ahan, W. K. Lee, and I. Chung, “Thermoresponsive N-vinyl caprolactam grafted sodium alginate hydrogel beads for the controlled release of an anticancer drug,” Cellulose, vol. 20, no. 3, p. 1261, 2013. View at Publisher · View at Google Scholar
  63. S.-C. Chen, Y.-C. Wu, F.-L. Mi, Y.-H. Lin, L.-C. Yu, and H.-W. Sung, “A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery,” Journal of Controlled Release, vol. 96, no. 2, pp. 285–300, 2004. View at Publisher · View at Google Scholar · View at Scopus
  64. B. Katzbauer, “Properties and applications of xanthan gum,” Polymer Degradation and Stability, vol. 59, no. 1–3, pp. 81–84, 1998. View at Google Scholar · View at Scopus
  65. S. S. Bhattacharya, A. Mishra, D. K. Pal et al., “Synthesis and characterization of poly(acrylic acid) poly(vinyl alcohol)-xanthan gum interpenetrating network (IPN) superabsorbent polymeric composites,” Polymer Plastic Technology and Engineering, vol. 51, pp. 876–882, 2012. View at Publisher · View at Google Scholar
  66. S. Tripathy and M. K. Das, “Guar gum: present status and applications,” Journal of Pharmaceutical and Scientific Innovation, vol. 2, pp. 24–28, 2013. View at Google Scholar
  67. J. Varshosaz, N. Tavakoli, and S. A. Eram, “Use of natural gums and cellulose derivatives in production of sustained release metoprolol tablets,” Drug Delivery, vol. 13, no. 2, pp. 113–119, 2006. View at Publisher · View at Google Scholar · View at Scopus
  68. K. M. Reddy, V. R. Babu, M. Sairam et al., “Development of chitosan-guar gum semi-interpenetrating polymer network microspheres for controlled release of cefadroxil,” Designed Monomers and Polymers, vol. 9, no. 5, pp. 491–501, 2006. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Glicksman, “Utilization of Natural Polysaccharide Gums in the Food Industry,” Advances in Food Research, vol. 11, pp. 109–200, 1963. View at Publisher · View at Google Scholar · View at Scopus
  70. P. Dey, S. Maiti, and B. Sa, “Novel etherified locust bean gum-alginate hydrogels for controlled release of glipizide,” Journal of Biomaterials Science Polymer, vol. 24, pp. 663–683, 2013. View at Google Scholar