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Journal of Drug Delivery
Volume 2014 (2014), Article ID 670815, 23 pages
http://dx.doi.org/10.1155/2014/670815
Review Article

Carbon Nanotubes: An Emerging Drug Carrier for Targeting Cancer Cells

1School of Pharmaceutical Sciences, IFTM University, Moradabad, Uttar Pradesh 244001, India
2Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh 221005, India

Received 23 October 2013; Revised 26 January 2014; Accepted 12 March 2014; Published 24 April 2014

Academic Editor: Hans E. Junginger

Copyright © 2014 Vaibhav Rastogi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

During recent years carbon nanotubes (CNTs) have been attracted by many researchers as a drug delivery carrier. CNTs are the third allotropic form of carbon-fullerenes which were rolled into cylindrical tubes. To be integrated into the biological systems, CNTs can be chemically modified or functionalised with therapeutically active molecules by forming stable covalent bonds or supramolecular assemblies based on noncovalent interactions. Owing to their high carrying capacity, biocompatibility, and specificity to cells, various cancer cells have been explored with CNTs for evaluation of pharmacokinetic parameters, cell viability, cytotoxicty, and drug delivery in tumor cells. This review attempts to highlight all aspects of CNTs which render them as an effective anticancer drug carrier and imaging agent. Also the potential application of CNT in targeting metastatic cancer cells by entrapping biomolecules and anticancer drugs has been covered in this review.