Table of Contents Author Guidelines Submit a Manuscript
Journal of Drug Delivery
Volume 2014, Article ID 746325, 7 pages
http://dx.doi.org/10.1155/2014/746325
Research Article

Evaluating Cytotoxicity of Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide on SK-OV-3 Cells

1Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, P.O. Box 81745-359, Isfahan 81746-73461, Iran
2Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran

Received 1 January 2014; Revised 28 March 2014; Accepted 28 March 2014; Published 24 April 2014

Academic Editor: Sami M. Nazzal

Copyright © 2014 Parviz Mohammadi Ghalaei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. E. Guppy, P. D. Nathan, and G. J. S. Rustin, “Epithelial ovarian cancer: a review of current management,” Clinical Oncology, vol. 17, no. 6, pp. 399–411, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. P. J. O'Dwyer, B. Leyland-Jones, and M. T. Alonso, “Etoposide (VP-16-213). Current status of an active anticancer drug,” New England Journal of Medicine, vol. 312, no. 11, pp. 692–700, 1985. View at Google Scholar · View at Scopus
  3. R. E. Taylor, T. J. McElwain, A. Barrett, and M. J. Peckham, “Etoposide as a single agent in relapsed advanced lymphomas. A phase II study,” Cancer Chemotherapy and Pharmacology, vol. 7, no. 2-3, pp. 175–177, 1982. View at Google Scholar · View at Scopus
  4. S. Mukherjee, S. Ray, and R. S. Thakur, “Solid lipid nanoparticles: a modern formulation approach in drug delivery system,” Indian Journal of Pharmaceutical Sciences, vol. 71, no. 4, pp. 349–358, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. H. Li, X. Zhao, Y. Ma, G. Zhai, L. Li, and H. Lou, “Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles,” Journal of Controlled Release, vol. 133, no. 3, pp. 238–244, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Uner and G. Yener, “Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives,” International Journal of Nanomedicine, vol. 2, no. 3, pp. 289–300, 2007. View at Google Scholar
  7. W. Mehnert and K. Mäder, “Solid lipid nanoparticles: production, characterization and applications,” Advanced Drug Delivery Reviews, vol. 47, no. 2-3, pp. 165–196, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. R. H. Müller, K. Mäder, and S. Gohla, “Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, no. 1, pp. 161–177, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. K. S. Yadav, K. Chuttani, A. K. Mishra, and K. K. Sawant, “Long circulating nanoparticles of etoposide using PLGA-MPEG and PLGA-pluronic block copolymers: characterization, drug-release, blood-clearance, and biodistribution studies,” Drug Development Research, vol. 71, no. 4, pp. 228–239, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. L. H. Reddy, R. K. Sharma, K. Chuttani, A. K. Mishra, and R. R. Murthy, “Etoposide-incorporated tripalmitin nanoparticles with different surface charge: formulation, characterization, radiolabeling, and biodistribution studies,” The AAPS Journal, vol. 6, no. 3, p. e23, 2004. View at Google Scholar · View at Scopus
  11. B. A. Nevius, Y. P. Chen, J. L. Ferry, and A. W. Decho, “Surface-functionalization effects on uptake of fluorescent polystyrene nanoparticles by model biofilms,” Ecotoxicology, vol. 21, no. 8, pp. 2205–2213, 2012. View at Publisher · View at Google Scholar
  12. G. Kremser, T. Rath, B. Kunert et al., “Structural characterisation of alkyl amine-capped zinc sulphide nanoparticles,” Journal of Colloid and Interface Science, vol. 369, no. 1, pp. 154–159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Sun, Synthesis of gold-amine nanoparticles of various sizes using two different methods [M.S. thesis], Department of Chemistry, Kansas State University, Manhattan, Kan, USA, 2010.
  14. Y. Luo, N. J. Bernshaw, Z.-R. Lu, J. Kopecek, and G. D. Prestwich, “Targeted delivery of doxorubicin by HPMA copolymer-hyaluronan bioconjugates,” Pharmaceutical Research, vol. 19, no. 4, pp. 396–402, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. K. Akima, H. Ito, Y. Iwata et al., “Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity,” Journal of Drug Targeting, vol. 4, no. 1, pp. 1–8, 1996. View at Google Scholar · View at Scopus
  16. A. Rosato, A. Banzato, G. De Luca et al., “HYTAD1-p20: a new paclitaxel-hyaluronic acid hydrosoluble bioconjugate for treatment of superficial bladder cancer,” Urologic Oncology: Seminars and Original Investigations, vol. 24, no. 3, pp. 207–215, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. D. Peer and R. Margalit, “Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models,” International Journal of Cancer, vol. 108, no. 5, pp. 780–789, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Lee, H. Mok, S. Lee, Y. Oh, and T. G. Park, “Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels,” Journal of Controlled Release, vol. 119, no. 2, pp. 245–252, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. H. Yun, D. J. Goetz, P. Yellen, and W. Chen, “Hyaluronan microspheres for sustained gene delivery and site-specific targeting,” Biomaterials, vol. 25, no. 1, pp. 147–157, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Varshosaz, P. Mohammadi Ghalaei, and F. Hassanzadeh, “Hyaluronate targeted solid lipid nanoparticles of etoposide: optimization and in vitro characterization,” Journal of Nanomaterials, vol. 2014, Article ID 345845, 12 pages, 2014. View at Publisher · View at Google Scholar
  21. J. Varshosaz, S. Eskandari, and M. Tabakhian, “Production and optimization of valproic acid nanostructured lipid carriers by the Taguchi design,” Pharmaceutical Development and Technology, vol. 15, no. 1, pp. 89–96, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Ataman-Önal, S. Munier, A. Ganée et al., “Surfactant-free anionic PLA nanoparticles coated with HIV-1 p24 protein induced enhanced cellular and humoral immune responses in various animal models,” Journal of Controlled Release, vol. 112, no. 2, pp. 175–185, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. V. Teeranachaideekul, E. B. Souto, V. B. Junyaprasert, and R. H. Müller, “Cetyl palmitate-based NLC for topical delivery of Coenzyme Q10-development, physicochemical characterization and in vitro release studies,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 67, no. 1, pp. 141–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Itamochi, T. Oishi, M. Shimada et al., “Inhibiting the mTOR pathway synergistically enhances cytotoxicity in ovarian cancer cells induced by etoposide through upregulation of c-Jun,” Clinical Cancer Research, vol. 17, no. 14, pp. 4742–4750, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. W. Strober, Monitoring Cell Growth. Current Protocols InImmunology, John Wiley & Sons, Washington, DC, USA, 2001.
  26. Y. H. Bae and K. Park, “Targeted drug delivery to tumors: myths, reality and possibility,” Journal of Controlled Release, vol. 153, no. 3, pp. 198–205, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. S. K. Hobbs, W. L. Monsky, F. Yuan et al., “Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 8, pp. 4607–4612, 1998. View at Publisher · View at Google Scholar · View at Scopus
  28. F. Yuan, M. Dellian, D. Fukumura et al., “Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size,” Cancer Research, vol. 55, no. 17, pp. 3752–3756, 1995. View at Google Scholar · View at Scopus
  29. K. Y. Choi, K. H. Min, J. H. Na et al., “Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution,” Journal of Materials Chemistry, vol. 19, no. 24, pp. 4102–4107, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Miglietta, R. Cavalli, C. Bocca, L. Gabriel, and M. Rosa Gasco, “Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel,” International Journal of Pharmaceutics, vol. 210, no. 1-2, pp. 61–67, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Serpe, M. G. Catalano, R. Cavalli et al., “Cytotoxicity of anticancer drugs incorporated in solid lipid nanoparticles on HT-29 colorectal cancer cell line,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 58, no. 3, pp. 673–680, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. B. Saliou, O. Thomas, N. Lautram et al., “Development and in vitro evaluation of a novel lipid nanocapsule formulation of etoposide,” European Journal of Pharmaceutical Sciences, vol. 50, no. 2, pp. 172–180, 2013. View at Google Scholar
  33. A. Lamprecht and J. Benoit, “Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition,” Journal of Controlled Release, vol. 112, no. 2, pp. 208–213, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Nasti, N. M. Zaki, P. De Leonardis et al., “Chitosan/TPP and chitosan/TPP-hyaluronic acid nanoparticles: systematic optimisation of the preparative process and preliminary biological evaluation,” Pharmaceutical Research, vol. 26, no. 8, pp. 1918–1930, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Han, Q. Lv, X. J. Tang et al., “Overcoming drug resistance of MCF-7/ADR cells by altering intracellular distribution of doxorubicin via MVP knockdown with a novel siRNA polyamidoamine-hyaluronic acid complex,” Journal of Controlled Release, vol. 163, no. 2, pp. 136–144, 2012. View at Google Scholar
  36. X. G. Zhang, J. Miao, Y. Q. Dai, Y. Z. Du, H. Yuan, and F. Q. Hu, “Reversal activity of nanostructured lipid carriers loading cytotoxic drug in multi-drug resistant cancer cells,” International Journal of Pharmaceutics, vol. 361, no. 1-2, pp. 239–244, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. H. J. Cho, H. Y. Yoon, H. Koo et al., “Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic® for tumor-targeted delivery of docetaxel,” Biomaterials, vol. 32, no. 29, pp. 7181–7190, 2011. View at Publisher · View at Google Scholar · View at Scopus