Research Article
Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets
Table 4
Different properties of the formulated FDTs.
| | Code | Parameter | Diameter
(mm) | Thickness
(mm) | Friability
(%) | Hardness
(kg/cm2) | TS*
(MN/m2) | WT*
(Sec) | WAR*
(%) | DT*
(Sec) | CU*
(%) | TPF* |
(%) | |
| | F1 | 6.74 ± 0.03 | 3.56 ± 0.03 | 0.89 ± 0.04 | 3.11 ± 0.10 | 0.47 ± 0.15 | 68 ± 1.13 | 40 ± 0.11 | 73 ± 3 | 98.99 ± 0.2 | 0.81 | 18.9 | 19 | | F2 | 6.73 ± 0.04 | 3.51 ± 0.04 | 0.91 ± 0.02 | 3.15 ± 0.07 | 0.47 ± 0.05 | 68 ± 1.29 | 42 ± 0.11 | 73 ± 1 | 99.1 ± 0.15 | 0.82 | 17.5 | 24 | | F3 | 6.74 ± 0.05 | 3.55 ± 0.05 | 0.89 ± 0.05 | 3.09 ± 0.11 | 0.47 ± 0.11 | 67 ± 1.11 | 46 ± 0.09 | 71 ± 2 | 97.27 ± 0.9 | 0.81 | 18.7 | 21 | | F4 | 6.73 ± 0.01 | 3.59 ± 0.05 | 0.90 ± 0.03 | 3.10 ± 0.02 | 0.47 ± 0.09 | 66 ± 1.14 | 46 ± 0.10 | 71 ± 3 | 96.59 ± 0.5 | 0.80 | 19.4 | 25 | | F5 | 6.74 ± 0.01 | 3.51 ± 0.05 | 0.76 ± 0.04 | 3.50 ± 0.11 | 0.48 ± 0.05 | 33 ± 1.14 | 98 ± 0.04 | 48 ± 2 | 96.50 ± 0.3 | 0.63 | 36.7 | 43 | | F6 | 6.74 ± 0.02 | 3.55 ± 0.04 | 0.73 ± 0.05 | 3.56 ± 0.08 | 0.48 ± 0.01 | 33 ± 1.67 | 96 ± 0.04 | 46 ± 3 | 99.1 ± 0.15 | 0.62 | 37.3 | 43 | | F7 | 6.74 ± 0.01 | 3.55 ± 0.05 | 0.71 ± 0.02 | 3.70 ± 0.15 | 0.56 ± 0.18 | 32 ± 1.10 | 101 ± 0.05 | 44 ± 1 | 98.35 ± 0.2 | 0.62 | 37.3 | 45 | | F8 | 6.74 ± 0.03 | 3.56 ± 0.03 | 0.67 ± 0.03 | 3.75 ± 0.21 | 0.55 ± 0.08 | 31 ± 1.40 | 103 ± 0.02 | 40 ± 2 | 99.23 ± 0.5 | 0.62 | 37.5 | 47 | | F9 | 6.73 ± 0.04 | 3.55 ± 0.02 | 0.55 ± 0.01 | 4.00 ± 0.18 | 0.60 ± 0.19 | 23 ± 1.34 | 108 ± 0.03 | 40 ± 6 | 99.12 ± 0.4 | 0.54 | 42.6 | 50 | | F10 | 6.74 ± 0.05 | 3.54 ± 0.07 | 0.54 ± 0.05 | 3.80 ± 0.15 | 0.57 ± 0.06 | 22 ± 1.25 | 100 ± 0.02 | 35 ± 3 | 98.92 ± 0.7 | 0.57 | 43.5 | 50 | | F11 | 6.73 ± 0.03 | 3.56 ± 0.04 | 0.55 ± 0.03 | 3.70 ± 0.17 | 0.56 ± 0.11 | 23 ± 1.05 | 106 ± 0.06 | 36 ± 2 | 97.27 ± 0.9 | 0.57 | 42.3 | 55 | | F12 | 6.73 ± 0.02 | 3.53 ± 0.03 | 0.51 ± 0.04 | 4.10 ± 0.2 | 0.62 ± 0.15 | 23 ± 1.38 | 110 ± 0.04 | 32 ± 7 | 96.59 ± 0.5 | 0.56 | 42.6 | 53 | | F13 | 6.74 ± 0.03 | 3.55 ± 0.04 | 0.41 ± 0.07 | 4.20 ± 0.27 | 0.73 ± 0.08 | 14 ± 1.52 | 121 ± 0.08 | 26 ± 2 | 99.15 ± 0.1 | 0.41 | 58.2 | 50 | | F14 | 6.73 ± 0.01 | 3.51 ± 0.04 | 0.42 ± 0.02 | 4.25 ± 0.2 | 0.73 ± 0.20 | 14 ± 1.26 | 124 ± 0.07 | 24 ± 5 | 98.99 ± 0.2 | 0.39 | 59.5 | 52 | | F15 | 6.74 ± 0.03 | 3.55 ± 0.06 | 0.44 ± 0.04 | 4.30 ± 0.10 | 0.76 ± 0.18 | 13 ± 1.15 | 125 ± 0.03 | 22 ± 3 | 99.75 ± 1.0 | 0.40 | 59.9 | 62 | | F16 | 6.74 ± 0.01 | 3.59 ± 0.05 | 0.47 ± 0.07 | 4.20 ± 0.45 | 0.79 ± 0.19 | 14 ± 1.40 | 128 ± 0.05 | 22 ± 4 | 99.12 ± 0.3 | 0.41 | 61.2 | 64 |
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TS*: tensile strength; WT*: wetting time; WAR*: water absorption ratio; DT*: disintegration time; CU*: content uniformity; TPF*: tablet packing fraction; *: porosity.
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