Research Article
Formulation and Evaluation of Optimized Oxybenzone Microsponge Gel for Topical Delivery
Table 3
Skin irritation test.
| | Animal number | Reaction | Placebo gel (24 h) | Placebo gel (72 h) | M9 gel (24 h) | M9 gel (72 h) | Marketed lotion (24 h) | Marketed lotion (72 h) |
| | 1 | Erythema | 0 | 0 | 0 | 0 | 1 | 1 | | 2 | Erythema | 0 | 0 | 1 | 0 | 2 | 1 | | 3 | Erythema | 1 | 0 | 1 | 0 | 1 | 1 | | 4 | Erythema | 0 | 0 | 1 | 0 | 1 | 1 | | Primary irritation index (PII ) | — | 1/8 = 0.125 | 3/8 = 0.375 | 9/8 = 1.12 | | — | Negligible irritation | Negligible irritation | Slight irritation |
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