Reassessing the Role of Intra-Arterial Drug Delivery for Glioblastoma Multiforme Treatment

Figure 2

Dedrick model of intracarotid delivery. This pictorial representation of the mathematical model demonstrates that IA drug delivery is most efficient when regional flow () is low, regional extraction is high, and systemic clearance is rapid. : concentration, : volume, CL: clearance, and : regional blood flow.