Research Article
Design and Characterization of Buccoadhesive Liquisolid System of an Antihypertensive Drug
Table 6
Postcompression evaluation of buccoadhesive tablets.
| | Parameter | | | | | | | | | | |
| | Friability % | 0.3 ± 0.01 | 0.1 ± 0.01 | 0.2 ± 0.01 | 0.1 ± 0.01 | 0.1 ± 0.01 | 0.2 ± 0.01 | 0.1 ± 0.01 | 0.1 ± 0.01 | 0.1 ± 0.01 | 0.2 ± 0.01 |
| | Hardness (kg/cm2) | 8.0 ± 0.73 | 7.0 ± 0.25 | 7.0 ± 0.16 | 6.0 ± 0.35 | 7.0 ± 0.44 | 8.0 ± 0.17 | 7.0 ± 0.37 | 6.0 ± 0.45 | 8.0 ± 1.24 | 9.0 ± 0.68 |
| | Thickness (mm) | 3.87 ± 0.04 | 4.01 ± 0.05 | 4.02 ± 0.06 | 4.02 ± 0.09 | 4.01 ± 0.07 | 4.03 ± 0.08 | 4.06 ± 0.04 | 4.03 ± 0.05 | 4.01 ± 0.07 | 4.04 ± 0.04 |
| | Drug content (%) | 99.25 ± 2.21 | 100.07 ± 2.7 | 98.76 ± 1.10 | 110.2 ± 1.5 | 98.15 ± 2.14 | 98.87 ± 2.18 | 97.45 ± 2.25 | 99.33 ± 2.18 | 100.5 ± 1.10 | 98.63 ± 2.21 |
| | Bioadhesive strength (g) | 30.0 ± 1.5 | 34.0 ± 1.6 | 39.0 ± 1.5 | 37.0 ± 1.3 | 38.0 ± 1.6 | 37.0 ± 0.7 | 35.0 ± 0.5 | 38.0 ± 1.4 | 36.0 ± 1.6 | 35.0 ± 1.5 |
| | Ex vivo residence time (h) | 4.0 ± 0.2 | 6.0 ± 0.4 | 7.0 ± 0.4 | 8.0 ± 0.3 | 8.0 ± 0.4 | 6.0 ± 0.2 | 7.0 ± 0.3 | 7.0 ± 0.3 | 8.0 ± 0.4 | 7.0 ± 0.3 |
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