Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Table 3

Composition of Nateglinide sustained release tablets.

Ingredients	N1	N2	N3	N4	N5	N6	N7	N8	N9	N10	N11	N12	N13
Drug	60	60	60	60	60	60	60	60	60	60	60	60	60
HPMC	30	45	60	—	—	—	—	—	45	—	—	—	—
Guar gum	—	—	—	30	45	60	75	—	—	60	60	60	60
X-gum	—	—	—	—	—	—	—	75	45	45	—	—	—
EC	—	—	—	—	—	—	—	—	—	—	15	30	15
Mannitol	—	—	—	—	—	—	—	—	—	—	—	—	72
MCC	180	165	150	180	165	150	135	135	120	129	135	120	72
PVP	15	15	15	15	15	15	15	15	15	15	15	15	15
Mg. st.	7.5	7.5	7.5	7.5	7.5	7.5	7.5	7.5	7.5	6	7.5	7.5	6
Talc	7.5	7.5	7.5	7.5	7.5	7.5	7.5	7.5	7.5	—	7.5	7.5	—
Total wt.	300	300	300	300	300	300	300	300	300	300	300	300	300

HPMC: hydroxy propyl methyl cellulose; X-gum: Xanthan gum; EC: ethyl cellulose; MCC: microcrystalline cellulose; PVP: polyvinyl pyrrolidone, Mg. st.: magnesium stearate.