Research Article

Formulation and In Vitro Evaluation of Bilayer Tablets of Nebivolol Hydrochloride and Nateglinide for the Treatment of Diabetes and Hypertension

Table 4

Diffusion exponent and solute release mechanism (Korsemeyer equation/Peppas model).

Diffusion exponent ()Drug release mechanism

0.45Fickian diffusion
0.45 < = 0.89Anomalous (non-Fickian) diffusion
0.89Case-II transport
> 0.89Super case-II transport