Design and Evaluation of Voriconazole Loaded Solid Lipid Nanoparticles for Ophthalmic Application

Table 3

Kinetic profiles of in vitro drug release from solid lipid nanoparticles through dialysis membrane prepared by different techniques.

Batches	Zero-order model		First-order model		Higuchi model		Korsmeyer-Peppas model			Hixson-Crowell model
	VUSLN-1	0.8875	0.1075	0.9882	−0.0011	0.9925	3.0573	0.9957	0.4559	0.6995	0.9871	−0.0026
VUSLN-2	0.9276	0.1092	0.9891	−0.001	0.9917	3.2493	0.9944	0.5081	0.4820	0.9909	−0.0026
VUSLN-3	0.9526	0.1044	0.9852	−0.001	0.9919	3.3457	0.9949	0.5718	0.2854	0.9922	−0.0026
VUSLN-4	0.9773	0.1013	0.9323	−0.001	0.9793	3.4423	0.9923	0.6257	0.110	0.9678	−0.0027
VUSLN-5	0.9789	0.1004	0.9650	−0.0008	0.9720	3.1781	0.9885	0.6537	0.0072	0.9786	−0.0022
VMSLN-6	0.9632	0.1189	0.9245	−0.0013	0.9285	3.6661	0.9992	0.5843	0.2800	0.9640	−0.0032
VMSLN-7	0.9589	0.1145	0.8832	−0.0011	0.9581	3.5647	0.9824	0.6181	0.1620	0.9279	−0.0029
VMSLN-8	0.9601	0.1127	0.8738	−0.0011	0.9449	3.5609	0.9762	0.6635	0.020	0.9171	−0.0028
VMSLN-9	0.9653	0.1119	0.8609	−0.0010	0.9371	3.5845	0.9778	0.7037	0.1072	0.9078	−0.0028
VMSLN-10	0.9908	0.0945	0.960	−0.0007	0.9667	3.1574	0.9906	0.8909	0.7185	0.9744	−0.002