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Journal of Drug Delivery
Volume 2016 (2016), Article ID 7913616, 9 pages
http://dx.doi.org/10.1155/2016/7913616
Research Article

Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications

College of Engineering, University of Georgia, Athens, GA 30602, USA

Received 11 February 2016; Revised 29 April 2016; Accepted 4 May 2016

Academic Editor: Viness Pillay

Copyright © 2016 Marcus J. Goudie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microfluidics has many drug delivery applications due to the ability to easily create complex device designs with feature sizes reaching down to the 10s of microns. In this work, three different microchannel designs for an implantable device are investigated for treatment of ocular diseases such as glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. Devices were fabricated using polydimethylsiloxane (PDMS) and soft lithography techniques, where surface chemistry of the channels was altered using 2-[methoxy(polyethyleneoxy)propyl]trimethoxysilane (PEG-silane). An estimated delivery rate for a number of common drugs was approximated for each device through the ratio of the diffusion coefficients for the dye and the respective drug. The delivery rate of the model drugs was maintained at a physiological condition and the effects of channel design and surface chemistry on the delivery rate of the model drugs were recorded over a two-week period. Results showed that the surface chemistry of the device had no significant effect on the delivery rate of the model drugs. All designs were successful in delivering a constant daily dose for each model drug.