Investigation of Diffusion Characteristics through Microfluidic Channels for Passive Drug Delivery Applications

Table 1

Dosing and diffusion characteristics of common drugs to treat ocular diseases. Diffusion coefficient of Toluidine Blue calculated using Stokes-Einstein approximation.

Drug name (type)	Diffusion coefficient (cm^2/s)	Average dosage (nL/min)	Injection amounts/periods	Molecular weight	Molar delivery (nmol/day)	References
Macugen (pegaptanib sodium)	3 × 10^−7	0.2083	3 mg/10 days	400 kDa	6.00	[20]
Lucentis (ranibizumab)	2.08 × 10^−7	0.0124	0.5 mg/month	500 kDa	0.35	[21]
Intravitreal Avastin (bevacizumab)	1.25 × 10^−7	0.0289	1.25 mg/month	100 kDa	0.28	[22]
Fluocinolone Acetonide	2.3 × 10^−7	0.0744	15 mg/20 weeks	400 Da	237.04	[23, 24]
Toluidine Blue	1.42 × 10^−5
Rhodamine B	4.2 × 10^−6					[25]