Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Figure 6

pH-dependent release of IT-147 by dialysis. The iron-stabilized IT-147 formulation demonstrates stability at physiological pH and a pH-dependent release of epothilone D as the pH decreases, whereas the unstabilized formulation releases the drug payload at all pH levels tested within the 6-hour dialysis assay.