Table 1: Physiochemical characterization of epothilone D pilot formulations with iron-hydroxamate or disulfide bond stabilization. Formulations were performed with each polymer listed as an entry number and characterized by drug weight loading, efficiency, particle size, and dialysis above and below the critical micelle concentration. Entry numbers 1 and 7 represent the leads selected for screening, and entry number 2 represents the scaled-up lead formulation.

Entry numberPolymer core blockPolymer stabilizing blockWeight loading (% w/w)Efficiency (%)Average diameter (nm)Dialysis > CMC (% remaining)Dialysis < CMC (% remaining)

1D-/
L-/
D-
NHOH3.466709060
2D-/
L-/
D-
NHOH4.491759468
3D-/
L-
NHOH3.364708025
4D-/
L-/
D-
NHOH3.058919128
5D-/
L-/
D-Asp5
NHOH1.733978228
6D-/
L-/
D-
NHOH0.917>20055<10
7L-/
D-
Cysteine3.772689438
8D-/
L-
Cysteine2.956868711
9D-/
L-
Cysteine0.1<135NDND
10L-/
D-
Cysteine0.1<1>20047<10
11D-/
L-/
D-
Cysteine0.51>200NDND