Table 2: Plasma pharmacokinetic screening of pilot epothilone D formulations compared to free drug. A cannulated rat model was used to determine the AUC, , and Clast of epothilone D in plasma for the first hour after administration.

Test articleAnimals per groupDose (mg/kg)  (hµg/mL) (µg/mL)Clast (µg/mL)

NHOH micelle31018.942.7 ± 4.97.7 ± 0.2
Cys micelle31010.634.0 ± 11.04.8 ± 1.1
Free drug3105.219.7 ± 4.11.6 ± 0.8