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Journal of Drug Delivery
Volume 2018, Article ID 5635010, 19 pages
https://doi.org/10.1155/2018/5635010
Review Article

Imagine the Superiority of Dry Powder Inhalers from Carrier Engineering

Dry Powder Inhaler Lab, Respiratory Formulations, Cipla R&D, LBS Marg Road, Vikhroli (West), Mumbai, Maharashtra 400079, India

Correspondence should be addressed to Piyush Mehta; moc.liamg@350uyip

Received 28 August 2017; Accepted 6 December 2017; Published 14 January 2018

Academic Editor: Philippe Maincent

Copyright © 2018 Piyush Mehta. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Inhalation therapy has strong history of more than 4000 years and it is well recognized around the globe within every culture. In early days, inhalation therapy was designed for treatment of local disorders such as asthma and other pulmonary diseases. Almost all inhalation products composed a simple formulation of a carrier, usually α-lactose monohydrate orderly mixed with micronized therapeutic agent. Most of these formulations lacked satisfactory pulmonary deposition and dispersion. Thus, various alternative carrier’s molecules and powder processing techniques are increasingly investigated to achieve suitable aerodynamic performance. In view of this fact, more suitable and economic alternative carrier’s molecules with advanced formulation strategies are discussed in the present review. Furthermore, major advances, challenges, and the future perspective are discussed.