Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections

Table 2

NMR comparison of chemical shifts of untreated ACV and PCL v. treated ACV:PCL.

	Chemical Shift in NMR (ppm)
	untr. PCL	untr. ACV	VASE-tr. ACV:PCL
TMS	0	0	0
PCL	1.3230		1.3230
	1.3471		1.3471
	1.5418		1.5418
	1.5613		1.5613
	1.5796		1.5796
	1.5957		1.5957
	1.6129		1.6129
	2.2566		2.2555
	2.2749		2.2749
	2.2933		2.2933
	3.4124		3.4124
	3.6163		3.6163
	3.6278		3.6289
	3.9840		3.9840
	4.0001		4.0001
	4.0172		4.0172
	4.1192		4.1192
ACV		3.5006	3.4983
		3.5075	3.5052
		4.4846	4.4852
		5.3609	5.3586
		6.3529	6.3609
		7.7252	7.7263
		10.5924	10.5351

untr. PCL: untreated PCL.
untr. AC:, untreated ACV.
VASE-tr. ACV:PCL: 30:70 (w:w) ACV:PCL treated by VASE method.
TMS: tetramethylsilane internal standard.