Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections
Table 3
Tm and ΔH comparison of untreated ACV and PCL v. treated ACV-PCL by DSC.
Material
Tm (°C)
ΔH (J/g)
untr. PCL
70.20 ± 0.10
73.0775 ± 1.3384
VASE-tr. 0:100 (w:w) ACV:PCL
63.84 ± 0.43
75.3630 ± 4.7970
VASE-tr. PCL in 10:90 (w:w) ACV:PCL device
65.60 ± .030
69.9022 ± 1.5858
VASE-tr. PCL in 30:70 (w:w) ACV:PCL device
65.58 ± 1.56
53.2311 ± 8.3285
VASE-tr. PCL in 50:50 (w:w) ACV:PCL device
65.01 ± 0.70
19.6963 ± 7.8685
VASE-tr. ACV in 10:90 (w:w) ACV:PCL device
238.49 ± 7.72
14.9521 ± 7.6689
VASE-tr. ACV in 30:70 (w:w) ACV:PCL device
233.87 ± 0.91
26.7761 ± 19.9455
VASE-tr. ACV in 50:50 (w:w) ACV:PCL device
232.81 ± 0.30
53.5217 ± 9.5136
VASE-tr. 100:0 ACV:PCL
233.82 ± 0.20
55.5956 ± 3.7339
untr. ACV
257.29 ± 0.34
143.5112 ± 23.3110
untr.: materials left untreated. VASE-tr.: materials treated by VASE method. Tm: melting point. ΔH: enthalpy of melting.
