Potential of Cocoa Pod Husk Pectin-Based Modified Release Capsules as a Carrier for Chronodelivery of Hydrocortisone in Sprague-Dawley Rats

Table 2

Pharmacokinetic parameters of the two CPH pectin-based hydrocortisone capsule formulations compared with a commercial immediate release hydrocortisone tablet.

Pharmacokinetic parameters	Commercial hydrocortisone tablet	Formulation A	Formulation B
(ng/ml)	15.32 ± 0.31	21.80 ± 1.99	20.84 ± 2.66
(h)	1 ± 0.20	6 ± 0.23	6 ± 0.35
t1/2 (h)	1.92 ± 1.48	7.26 ± 3.12	10.46 ± 4.43
AUC0→∞(ng.hr/ml)	42.78 ± 4.207	91.147 ± 2.013	117.463 ± 4.845
Rel. F (%)	100	213	274

p<0.05; p<0.001
: results obtained after extrapolations from concentration-time curves.