Advanced Lipid Technologies® (ALT®): A Proven Formulation Platform to Enhance the Bioavailability of Lipophilic Compounds
Figure 4
SC401 significantly increases DHA and EPA bioavailability in both rats (a, b) and humans (c, d) compared with Lovaza®. (a) Comparison of the area under the curve (AUC) of DHA at time 0 after treating adult rats with 2000 mg/kg of Lovaza® (720 mg DHA EE, blue), 1000 mg/kg of SC401 (257 mg DHA EE, red), or 2000 mg/kg of SC401 (514 mg DHA EE, dark red). (b) Comparison of the area under the curve (AUC) of EPA at time 0 after treating adult rats with 2000 mg/kg of Lovaza® (900 mg EPA EE, blue), 1000 mg/kg of SC401 (318 mg EPA EE, red), or 2000 mg/kg of SC401 (736 mg EPA EE, dark red). (c) Comparison of the AUC of DHA at time 0 after treating with Lovaza® (1480 mg of DHA EE, blue) or SC401 (638 mg DHA EE, red), in healthy humans. (d) Comparison of the AUC of EPA at time 0 after treating with Lovaza® (1928 mg EPA EE, blue) or SC401 (790 mg EPA EE, red), in healthy humans. p<0.001 vs Lovaza® and higher dose of SC401.