Journal of Diabetes Research

Journal of Diabetes Research / 2003 / Article

Open Access

Volume 4 |Article ID 759317 |

Anders A. F. Sima, Zhen-guo Li, Weixian Zhang, "The Insulin-Like Growth Factor System and Neurological Complications in Diabetes", Journal of Diabetes Research, vol. 4, Article ID 759317, 22 pages, 2003.

The Insulin-Like Growth Factor System and Neurological Complications in Diabetes

Received23 Dec 2002
Accepted06 Apr 2003


The IGF system plays vital roles in neuronal development, metabolism, regeneration and survival. It consists of IGF-I, IGF-II, insulin, IGF-I-receptor, and those of IGF-II and insulin as well as IGF-binding proteins. In the last decades it has become clear that perturbations of the IGF system play important roles in the pathogenesis of diabetic neurological complications. In the peripheral nervous system IGF-I, insulin, and C-peptide particularly in type 1 diabetes participate in the development of axonal degenerative changes and contributes to impaired regenerative capacities. These abnormalities of the IGF system appear to be less pronounced in type 2 diabetes, which may in part account for the relatively milder neurological complications in this type of diabetes. The members of the IGF system also provide anti-apoptotic effects on both peripheral and central nervous system neurons. Furthermore, both insulin and C-peptide and probably IGF-I possess gene regulatory capacities on myelin constituents and axonal cytoskeletal proteins. Therefore, replenishment of various members of the IGF system provides a reasonable rational for prevention and treatment of diabetic neurological complications.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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