Table of Contents Author Guidelines Submit a Manuscript
Experimental Diabetes Research
Volume 2007, Article ID 15803, 6 pages
Research Article

Further Studies on Antioxidant Potential and Protection of Pancreatic β-Cells by Embelia ribes in Experimental Diabetes

Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India

Received 14 July 2006; Revised 10 January 2007; Accepted 20 February 2007

Academic Editor: John Baynes

Copyright © 2007 Uma Bhandari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Mohan, “Why are Indians more prone to diabetes?” Journal of Association of Physicians of India, vol. 52, pp. 468–474, 2004. View at Google Scholar
  2. C. V. Anuradha and P. Ravikumar, “Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats,” Indian Journal of Physiology and Pharmacology, vol. 45, no. 4, pp. 408–420, 2001. View at Google Scholar
  3. J. W. Baynes, “Role of oxidative stress in development of complications in diabetes,” Diabetes, vol. 40, no. 4, pp. 405–412, 1991. View at Google Scholar
  4. D. Giugliano, A. Ceriello, and G. Paolisso, “Oxidative stress and diabetic vascular complications,” Diabetes Care, vol. 19, no. 3, pp. 257–267, 1996. View at Google Scholar
  5. B. Rodrigues and J. H. McNeill, “The diabetic heart: metabolic causes for the development of a cardiomyopathy,” Cardiovascular Research, vol. 26, no. 10, pp. 913–922, 1992. View at Google Scholar
  6. T. Myint, S. Hoshi, T. Ookawara, N. Miyazawa, K. Suzuki, and N. Taniguchi, “Immunological detection of glycated proteins in normal and streptozotocin-induced diabetic rats using anti hexitol-lysine IgG,” Biochimica et Biophysica Acta - Molecular Basis of Disease, vol. 1272, no. 2, pp. 73–79, 1995. View at Publisher · View at Google Scholar
  7. Y. Tajiri, C. Möller, and V. Grill, “Long term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits β cell function,” Endocrinology, vol. 138, no. 1, pp. 273–280, 1997. View at Publisher · View at Google Scholar
  8. M. Kawamura, J. W. Heinecke, and A. Chait, “Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway,” Journal of Clinical Investigation, vol. 94, no. 2, pp. 771–778, 1994. View at Google Scholar
  9. M. Hicks, L. Delbridge, D. K. Yue, and T. S. Reeve, “Increase in crosslinking of nonenzymatically glycosylated collagen induced by products of lipid peroxidation,” Archives of Biochemistry and Biophysics, vol. 268, no. 1, pp. 249–254, 1989. View at Publisher · View at Google Scholar
  10. M. Tiedge, S. Lortz, J. Drinkgern, and S. Lenzen, “Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells,” Diabetes, vol. 46, no. 11, pp. 1733–1742, 1997. View at Google Scholar
  11. M. S. Akhtar and M. R. Ali, “Study of anti diabetic effect of a compound medicinal plant prescription in normal and diabetic rabbits,” Journal of the Pakistan Medical Association, vol. 34, no. 8, pp. 239–244, 1984. View at Google Scholar
  12. P. Hördegen, J. Cabaret, H. Hertzberg, W. Langhans, and V. Maurer, “In vitro screening of six anthelmintic plant products against larval Haemonchus contortus with a modified methyl-thiazolyl-tetrazolium reduction assay,” Journal of Ethnopharmacology, vol. 108, no. 1, pp. 85–89, 2006. View at Publisher · View at Google Scholar
  13. V. N. Pandey, in Pharmacological Investigation of Certain Medicinal Plants and Compound Formulations Used in Ayurveda and Siddha, pp. 370–376, Central Council for Research in Ayurveda and Siddha, Yugantar Press, New Delhi, India, 1st edition, 1996.
  14. M. R. Vaidya Arya, “Sthaulya Cikitsa (treatment of obesity),” in A Compendium of Ayurvedic Medicine, Principles and Practice, pp. 335–339, Sri Satyaguru Publication. A division of Indian Book Centre, New Delhi, India, 1999. View at Google Scholar
  15. S. N. Tripathi, “Screening of hypoglycemic action in certain indigenous drugs,” Journal of Research in Indian Medicine, Yoga and Homeopathy, vol. 14, pp. 159–169, 1979. View at Google Scholar
  16. U. Bhandari, R. Kanojia, and K. K. Pillai, “Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats,” International Journal of Experimental Diabetes Research, vol. 3, no. 3, pp. 159–162, 2002. View at Publisher · View at Google Scholar
  17. A. Hyavarina and E. Nikkita, “Specific determination of blood glucose with ortho-toluidine,” Clinica Chimica Acta, vol. 7, pp. 140–143, 1962. View at Publisher · View at Google Scholar
  18. X.-F. Zhang and B. K.-H. Tan, “Antihyperglycaemic and anti-oxidant properties of Andrographis paniculata in normal and diabetic rats,” Clinical and Experimental Pharmacology and Physiology, vol. 27, no. 5-6, pp. 358–363, 2000. View at Publisher · View at Google Scholar
  19. L. A. Trivalli, P. H. Ranney, and H. T. Lai, “Glycated haemoglobin estimation,” The New England Journal of Medicine, vol. 284, pp. 353–354, 1971. View at Google Scholar
  20. E. Beutler, O. Duron, and B. M. Kelly, “Improved method for the determination of blood glutathione,” The Journal of Laboratory and Clinical Medicine, vol. 61, pp. 882–888, 1963. View at Google Scholar
  21. H. U. Bergmeyer and E. Bernt, “Lactate dehydrogenase UV-assay with pyruvate kinase and NADH,” in Methods of Enzymatic Analysis, H. U. Bergmeyer, Ed., pp. 574–579, Acadmic Press, London, UK, 2nd edition, 1974. View at Google Scholar
  22. S. R. Lum and G. Gambino, “A comparision of serum as heparinised plasma for routine chemistry tests,” American Journal of Clinical Pathology, vol. 61, pp. 108–112, 1974. View at Google Scholar
  23. C. G. Guglielmo, T. Piersma, and T. D. Williams, “A sport-physiological perspective on bird migration: evidence for flight-induced muscle damage,” The Journal of Experimental Biology, vol. 204, no. 15, pp. 2683–2690, 2001. View at Google Scholar
  24. H. Ohkawa, N. Ohishi, and K. Yagi, “Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction,” Analytical Biochemistry, vol. 95, no. 2, pp. 351–358, 1979. View at Publisher · View at Google Scholar
  25. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar
  26. J. Sedlak and R. H. Lindsay, “Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent,” Analytical Biochemistry, vol. 25, no. 1, pp. 192–205, 1968. View at Publisher · View at Google Scholar
  27. S. L. Marklund, “Pyrogallol oxidation,” in Handbook of Methods for Oxygen Radical Research, R. Greenwald, Ed., pp. 243–247, CRC Press, Boca Raton, Fla, USA, 1985. View at Google Scholar
  28. A. Clairborne, “Catalase activity,” in Handbook of Methods for Oxygen Radical Research, R. Greenwald, Ed., pp. 283–284, CRC Press, Boca Raton, Fla, USA, 1985. View at Google Scholar
  29. K. C. Gorray, D. Sorresso, S. A. Moak, J. Maimon, R. A. Greenwald, and B. S. Schneider, “Comparison of superoxide dismutase activities in isolated rat and guinea pig islets of Langerhans,” Hormone and Metabolic Research, vol. 25, no. 12, pp. 649–650, 1993. View at Google Scholar
  30. K. Grankvist, S. Marklund, and I. B. Taljedal, “Superoxide dismutase is a prophylactic against alloxan diabetes,” Nature, vol. 294, no. 5837, pp. 158–160, 1981. View at Publisher · View at Google Scholar
  31. P. S. M. Prince and V. P. Menon, “Effect of Syzigium cumini in plasma antioxidants on alloxan-induced diabetes in rats,” Journal of Clinical Biochemistry and Nutrition, vol. 25, no. 2, pp. 81–86, 1998. View at Google Scholar
  32. S.-H. Ihm, H. J. Yoo, S. W. Park, and J. H. Ihm, “Effect of aminoguanidine on lipid peroxidation in streptozotocin-induced diabetic rats,” Metabolism, vol. 48, no. 9, pp. 1141–1145, 1999. View at Google Scholar
  33. H. H. Hagar, “Folic acid and vitamin B12 supplementation attenuates isoprenaline-induced myocardial infarction in experimental hyperhomocysteinemic rats,” Pharmacological Research, vol. 46, no. 3, pp. 213–219, 2002. View at Publisher · View at Google Scholar
  34. T. S. Manjula, A. Geetha, and C. S. Devi, “Effect of aspirin on isoproterenol induced myocardial infarction—a pilot study,” Indian Journal of Biochemistry and Biophysics, vol. 29, no. 4, pp. 378–379, 1992. View at Google Scholar
  35. J. M. McCord, B. B. Keele Jr., and I. Fridovich, “An enzyme-based theory of obligate anaerobiosis: the physiological function of superoxide dismutase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 68, no. 5, pp. 1024–1027, 1971. View at Publisher · View at Google Scholar
  36. R. N. Chopra, I. C. Chopra, K. L. Handa, and L. D. Kapur, “Medicinal plants in diabetes,” in Indegenous Drugs of India, P. Gupta, Ed., pp. 314–319, Dhur and Sons, Calcutta, India, 2nd edition, 1958. View at Google Scholar
  37. M. A. Satheesh and L. Pari, “Antioxidant effect of Boehavia diffusa L. in tissues of alloxau - induced diabetic rats,” Indian Journal of Experimental Biology, vol. 42, pp. 982–992, 2004. View at Google Scholar
  38. M. Sreepriya and G. Bali, “Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats,” Molecular and Cellular Biochemistry, vol. 284, no. 1-2, pp. 49–55, 2006. View at Publisher · View at Google Scholar
  39. G. B. Sajithlal, P. Chithra, and G. Chandrakasan, “Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats,” Biochemical Pharmacology, vol. 56, no. 12, pp. 1607–1614, 1998. View at Publisher · View at Google Scholar
  40. N. Taniguchi, H. Kaneto, M. Asahi et al., “Involvement of glycation and oxidative stress in diabetic macroangiopathy,” Diabetes, vol. 45, 3, pp. S81–S83, 1996. View at Google Scholar
  41. M. J. Haller, M. S. Stalvey, and J. H. Silverstein, “Predictors of control of diabetes: monitoring may be the key,” Journal of Pediatrics, vol. 144, no. 5, pp. 660–661, 2004. View at Publisher · View at Google Scholar