Effect of <i>Siraitia Grosvenorii</i> Polysaccharide on Glucose and Lipid of Diabetic Rabbits
Induced by Feeding High Fat/High Sucrose Chow

Lin, Guo-Ping; Jiang, Tao; Hu, Xiao-Bo; Qiao, Xin-Hui; Tuo, Qin-Hui

doi:https://doi.org/10.1155/2007/67435

Journal of Diabetes Research

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Research Article | Open Access

Volume 2007 | Article ID 067435 | https://doi.org/10.1155/2007/67435

Effect of Siraitia Grosvenorii Polysaccharide on Glucose and Lipid of Diabetic Rabbits Induced by Feeding High Fat/High Sucrose Chow

Guo-Ping Lin,¹Tao Jiang,¹Xiao-Bo Hu,¹Xin-Hui Qiao,¹and Qin-Hui Tuo¹

Academic Editor: Subrata Chakrabarti

Received06 Apr 2007

Accepted19 Oct 2007

Published09 Dec 2007

Abstract

The Siraitia grosvenorii polysaccharide (SGP) from the Siraitia grosvenorii (Swingle) was isolated and purified. The therapeutic effects of SGP on diabetic rabbits induced by feeding high fat/high sucrose chow were studied. After administration of SGP for 4 weeks, the fasting blood glucose (FBG), plasma insulin levels (INS), plasma total cholesterol (TC), triglyceride (TG), and HDL-C were assayed. The results showed that administration of SGP can significantly decrease plasma total cholesterol, triglyceride, and glucose levels; and increase HDL-C levels after 4 weeks of treatment. The antihyperglycaemic effect of SGP at dose of 100 mg⋅kg⁻¹ bw was the most significant in three dosage groups. Furthermore, SGP could restore the blood lipid levels of diabetic rabbits (P<.05). These data indicate that SGP not only ameliorates the lipid disorder, but also lowers plasma glucose levels. So SGP have obvious glucose-lowering effect on hyperglycaemic rabbits induced by feeding high fat/high sucrose chow, its mechanism may be related to amelioration of lipid metabolism and restoring the blood lipid levels of hyperglycaemic rabbits.

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Copyright

Copyright © 2007 Guo-Ping Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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