Phlorizin Prevents Glomerular Hyperfiltration but not Hypertrophy in Diabetic Rats

Table 3

Inulin clearances (GFR) in the experimental groups: $\text{C}=$ control, $\text{D}=$ diabetic, DPLZ = phlorizin-treated diabetic rats, CPLZ = phlorizin-treated controls. ${\text{C}}_{\text{inulin}}=$ clearance of inulin, Bw${\text{t}}_0=$ initial body weight, $V=$ urine flow rate during clearance experiment, MBP = mean blood pressure. Clearance values were normalized to 100 g of initial body weight. Results are expressed as mean ± SEM and compared using student's t-test.

	Control ($n=7$)	Diabetic ($n=5$)	DPLZ ($n=5$)	CPLZ ($n=5$)
${\text{C}}_{\text{inulin}}$ (ml·min^-1·100 g^-1)	$0.47\pm 0.02$	$0.84\pm {0.1}^{**}$	$0.43\pm {0.05}^{\#}$	$0.61\pm 0.07$
Bw${\text{t}}_0$ (g)	$203.2\pm 5.6$	$196.2\pm 1.5$	$200.2\pm 3.8$	$200\pm 2.7$
$V$ ($\mu$l·min^-1·100 g^-1)	$5.6\pm 0.5$	$9.6\pm {1.3}^{*}$	$13.\pm {3.1}^{*}$	$6\pm 0.7$
MBP (mmHg)	$126.6\pm 3.3$	$123.9\pm 4.2$	$121.8\pm 2.2$	$123.0\pm 2.3$

${}^{*}=P<.05$, ${}^{**}=P<.01$ compared to control. ${}^{\#}=P<.01$ compared to diabetic.