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Experimental Diabetes Research
Volume 2008, Article ID 672021, 6 pages
http://dx.doi.org/10.1155/2008/672021
Research Article

Effects of Oral Glucose Load on Endothelial Function and on Insulin and Glucose Fluctuations in Healthy Individuals

1Cardiology Research Clinic Y, Bispebjerg University Hospital, Copenhagen, NV 2400, Denmark
2Cardiology Department P and Laboratory, Gentofte University Hospital, Hellerup 2900, Denmark
3Internal Medicine Clinic I, Bispebjerg University Hospital, Copenhagen, NV 2400, Denmark
4Cardiology department, Rigshospitalet Univeristy Hospital, Copenhagen 2100, Denmark

Received 22 July 2007; Accepted 31 December 2007

Academic Editor: George King

Copyright © 2008 A. Major-Pedersen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background/aims. Postprandial hyperglycemia, an independent risk factor for cardiovascular disease, is accompanied by endothelial dysfunction. We studied the effect of oral glucose load on insulin and glucose fluctuations, and on postprandial endothelial function in healthy individuals in order to better understand and cope with the postprandial state in insulin resistant individuals. Methods. We assessed post-oral glucose load endothelial function (flow mediated dilation), plasma insulin, and blood glucose in 9 healthy subjects. Results. The largest increases in delta FMD values (fasting FMD value subtracted from postprandial FMD value) occurred at 3 hours after both glucose or placebo load, respectively: (P = .009) and (P = .15). Glucose and insulin concentrations achieved maximum peaks at one hour post-glucose load. Conclusion. Oral glucose load does not induce endothelial dysfunction in healthy individuals with mean insulin and glucose values of 5.6 mmol/L and 27.2 mmol/L, respectively, 2 hours after glucose load.