Research Article

Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents

Figure 5

Immunoelectron-microscopic detection of type VIII collagen in Descemet’s membrane by the colloidal gold labeling method. (a) In the cornea of a 15-week-old Wistar rat, the colloidal gold label is distributed diffusely in the membrane. (b) In the diabetic cornea of a 15-week-old GK rat, the gold marker is mainly observed in the internodal region of the long-spacing collagen. Scale bar, 100 nm.
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(a)
818341.fig.005b
(b)