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Experimental Diabetes Research
Volume 2008, Article ID 818341, 8 pages
http://dx.doi.org/10.1155/2008/818341
Research Article

Change in Long-Spacing Collagen in Descemet's Membrane of Diabetic Goto-Kakizaki Rats and Its Suppression by Antidiabetic Agents

1Department of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan
2Department of Anatomy, Yokohama City University School of Medicine, Kanazawa Ku, Fukuura 3-9, Yokohama, Kanagawa 236-0004, Japan
3Department of Biochemistry, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan

Received 24 January 2008; Revised 23 April 2008; Accepted 1 July 2008

Academic Editor: Timothy Kern

Copyright © 2008 Yoshihiro Akimoto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. R. Taylor and R. A. Kimsey, “Corneal epithelial basement membrane changes in diabetes,” Investigative Ophthalmology & Visual Science, vol. 20, no. 4, pp. 548–553, 1981. View at Google Scholar
  2. R. L. Engerman and P. J. Colquhoun, “Epithelial and mesothelial basement membranes in diabetic patients and dogs,” Diabetologia, vol. 23, no. 6, pp. 521–524, 1982. View at Publisher · View at Google Scholar
  3. Y. Akimoto, H. Kawakami, K. Yamamoto, E. Munetomo, T. Hida, and H. Hirano, “Elevated expression of O-GlcNAc-modified proteins and O-GlcNAc transferase in corneas of diabetic Goto-Kakizaki rats,” Investigative Ophthalmology & Visual Science, vol. 44, no. 9, pp. 3802–3809, 2003. View at Publisher · View at Google Scholar
  4. Y. Akimoto, K. Yamamoto, E. Munetomo et al., “Elevated post-translational modification of proteins by O-linked N-acetylglucosamine in various tissues of diabetic Goto-Kakizaki rats accompanied by diabetic complications,” Acta Histochemica et Cytochemica, vol. 38, no. 2, pp. 131–142, 2005. View at Publisher · View at Google Scholar
  5. Y. Akimoto, G. W. Hart, L. Wells et al., “Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats,” Glycobiology, vol. 17, no. 2, pp. 127–140, 2007. View at Publisher · View at Google Scholar
  6. N. Ohguro, M. Matsuda, Y. Ohashi, and M. Fukuda, “Topical aldose reductase inhibitor for correcting corneal endothelial changes in diabetic patients,” British Journal of Ophthalmology, vol. 79, no. 12, pp. 1074–1077, 1995. View at Publisher · View at Google Scholar
  7. L. A. Meyer, J. L. Ubels, and H. F. Edelhauser, “Corneal endothelial morphology in the rat. Effects of aging, diabetes, and topical aldose reductase inhibitor treatment,” Investigative Ophthalmology & Visual Science, vol. 29, no. 6, pp. 940–948, 1988. View at Google Scholar
  8. R. O. Schultz, M. Matsuda, R. W. Yee, H. F. Edelhauser, and K. J. Schultz, “Corneal endothelial changes in type I and type II diabetes mellitus,” American Journal of Ophthalmology, vol. 98, no. 4, pp. 401–410, 1984. View at Publisher · View at Google Scholar
  9. S. G. Levy, A. C. E. McCartney, H. Sawada, P. J. C. Dopping-Hepenstal, R. A. Alexander, and J. Moss, “Descemet's membrane in the iridocorneal-endothelial syndrome: morphology and composition,” Experimental Eye Research, vol. 61, no. 3, pp. 323–333, 1995. View at Publisher · View at Google Scholar
  10. S. G. Levy, J. Moss, H. Sawada, P. J. C. Dopping-Hepenstal, and A. C. E. McCartney, “The composition of wide-spaced collagen in normal and diseased Descemet's membrane,” Current Eye Research, vol. 15, no. 1, pp. 45–52, 1996. View at Publisher · View at Google Scholar
  11. U. Rehany, Y. Ishii, M. Lahav, and S. Rumelt, “Collagen pleomorphism in Descemet's membrane of streptozotocin-induced diabetic rats: an electron microscopy study,” Cornea, vol. 19, no. 3, pp. 390–392, 2000. View at Publisher · View at Google Scholar
  12. U. Rehany, Y. Ishii, M. Lahav, and S. Rumelt, “Ultrastructural changes in corneas of diabetic patients: an electron-microscopy study,” Cornea, vol. 19, no. 4, pp. 534–538, 2000. View at Publisher · View at Google Scholar
  13. Y. Goto, K. Suzuki, T. Ono, M. Sasaki, and T. Toyota, “Development of diabetes in the non-obese NIDDM rat (GK rat),” Advances in Experimental Medicine and Biology, vol. 246, pp. 29–31, 1988. View at Google Scholar
  14. S. Bisbis, D. Bailbe, M.-A. Tormo et al., “Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver,” American Journal of Physiology, vol. 265, no. 5, pp. E807–E813, 1993. View at Google Scholar
  15. K. Miyamoto, Y. Ogura, H. Nishiwaki et al., “Evaluation of retinal microcirculatory alterations in the Goto-Kakizaki rat. A spontaneous model of non-insulin-dependent diabetes,” Investigative Ophthalmology & Visual Science, vol. 37, no. 5, pp. 898–905, 1996. View at Google Scholar
  16. H. Sone, Y. Kawakami, Y. Okuda et al., “Ocular vascular endothelial growth factor levels in diabetic rats are elevated before observable retinal proliferative changes,” Diabetologia, vol. 40, no. 6, pp. 726–730, 1997. View at Publisher · View at Google Scholar
  17. A. Carmo, J. G. Cunha-Vaz, A. P. Carvalho, and M. C. Lopes, “Nitric oxide synthase activity in retinas from non-insulin-dependent diabetic Goto-Kakizaki rats: correlation with blood-retinal barrier permeability,” Nitric Oxide, vol. 4, no. 6, pp. 590–596, 2000. View at Publisher · View at Google Scholar
  18. M. Wakuta, N. Morishige, T.-I. Chikama, K. Seki, T. Nagano, and T. Nishida, “Delayed wound closure and phenotypic changes in corneal epithelium of the spontaneously diabetic Goto-Kakizaki rat,” Investigative Ophthalmology & Visual Science, vol. 48, no. 2, pp. 590–596, 2007. View at Publisher · View at Google Scholar
  19. H. Sawada, H. Konomi, and K. Hirosawa, “Characterization of the collagen in the hexagonal lattice of Descemet's membrane: its relation to type VIII collagen,” The Journal of Cell Biology, vol. 110, no. 1, pp. 219–227, 1990. View at Publisher · View at Google Scholar
  20. H. Sawada and F. Yazama, “Type VI collagen in the rat testis: monoclonal antibody, isolation, and localization during development,” Biology of Reproduction, vol. 50, no. 3, pp. 702–710, 1994. View at Publisher · View at Google Scholar
  21. Y. Akimoto, N. Yamakawa, K. Furukawa, K. Kimata, H. Kawakami, and H. Hirano, “Changes in distribution of the long form of type XII collagen during chicken corneal development,” Journal of Histochemistry & Cytochemistry, vol. 50, no. 6, pp. 851–862, 2002. View at Google Scholar
  22. Y. Akimoto, L. K. Kreppel, H. Hirano, and G. W. Hart, “Localization of the O-linked N-acetylglucosamine transferase in rat pancreas,” Diabetes, vol. 48, no. 12, pp. 2407–2413, 1999. View at Publisher · View at Google Scholar
  23. Y. Kitahara, K. Miura, K. Takesue et al., “Decreased blood glucose excursion by nateglinide ameliorated neuropathic changes in Goto-Kakizaki rats, an animal model of non-obese type 2 diabetes,” Metabolism: Clinical and Experimental, vol. 51, no. 11, pp. 1452–1457, 2002. View at Publisher · View at Google Scholar
  24. T. Mine, K. Miura, Y. Kitahara, A. Okano, and R. Kawamori, “Nateglinide suppresses postprandial hypertriglyceridemia in Zucker fatty rats and Goto-Kakizaki rats: comparison with voglibose and glibenclamide,” Biological & Pharmaceutical Bulletin, vol. 25, no. 11, pp. 1412–1416, 2002. View at Publisher · View at Google Scholar
  25. J. Kawai, M. Ohara-Imaizumi, Y. Nakamichi et al., “Insulin exocytosis in Goto-Kakizaki rat ß-cells subjected to long-term glinide or sulfonylurea treatment,” Biochemical Journal, vol. 412, no. 1, pp. 93–101, 2008. View at Publisher · View at Google Scholar
  26. T. Ikenoue, K. Okazaki, S. Fujitani et al., “Effect of a new hypoglycemic agent, A-4166 [(-)-N-(trans-4-isopropyl- cyclohexanecarbonyl)-D-phenylalanine], on postprandial blood glucose excursion: comparison with voglibose and glibenclamide,” Biological & Pharmaceutical Bulletin, vol. 20, no. 4, pp. 354–359, 1997. View at Google Scholar
  27. J. Ueda and B. Y. J. T. Yue, “Distribution of myocilin and extracellular matrix components in the corneoscleral meshwork of human eyes,” Investigative Ophthalmology & Visual Science, vol. 44, no. 11, pp. 4772–4779, 2003. View at Publisher · View at Google Scholar
  28. Y. Murata, H. Yoshioka, K. Iyama, and G. Usuku, “Distribution of type VI collagen in the bovine cornea,” Ophthalmic Research, vol. 21, no. 1, pp. 67–72, 1989. View at Google Scholar
  29. G. E. Marshall, A. G. Konstas, and W. R. Lee, “Immunogold fine structural localization of extracellular matrix components in aged human cornea. II. Collagen types V and VI,” Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 229, no. 2, pp. 164–171, 1991. View at Publisher · View at Google Scholar
  30. H. Sage, B. Trüeb, and P. Bornstein, “Biosynthetic and structural properties of endothelial cell type VIII collagen,” The Journal of Biological Chemistry, vol. 258, no. 21, pp. 13391–13401, 1983. View at Google Scholar
  31. P. D. Benya and S. R. Padilla, “Isolation and characterization of type VIII collagen synthesized by cultured rabbit corneal endothelial cells. A conventional structure replaces the interrupted-helix model,” The Journal of Biological Chemistry, vol. 261, no. 9, pp. 4160–4169, 1986. View at Google Scholar
  32. J. W. Rohen, E. Lütjen-Drecoll, C. Flügel, M. Meyer, and I. Grierson, “Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG),” Experimental Eye Research, vol. 56, no. 6, pp. 683–692, 1993. View at Publisher · View at Google Scholar
  33. T. L. van der Schaft, W. C. de Bruijn, C. M. Mooy, D. A. Ketelaars, and P. T. de Jong, “Is basal laminar deposit unique for age-related macular degeneration?” Archives of Ophthalmology, vol. 109, no. 3, pp. 420–425, 1991. View at Google Scholar
  34. S. I. Roth, E. L. Stock, and R. Jutabha, “Endothelial viral inclusions in Fuchs' corneal dystrophy,” Human Pathology, vol. 18, no. 4, pp. 338–341, 1987. View at Publisher · View at Google Scholar
  35. W. M. Bourne, D. H. Johnson, and R. J. Campbell, “The ultrastructure of Descemet's membrane. III. Fuch's dystrophy,” Archives of Ophthalmology, vol. 100, no. 12, pp. 1952–1955, 1982. View at Google Scholar
  36. J. D. Gottsch, C. Zhang, O. H. Sundin, W. R. Bell, W. J. Stark, and W. R. Green, “Fuchs corneal dystrophy: aberrant collagen distribution in an L450W Mutant of the COL8A2 gene,” Investigative Ophthalmology & Visual Science, vol. 46, no. 12, pp. 4504–4511, 2005. View at Publisher · View at Google Scholar
  37. J. D. Gottsch, O. H. Sundin, S. H. Liu et al., “Inheritance of a novel COL8A2 mutation defines a distinct early-onset subtype of Fuchs corneal dystrophy,” Investigative Ophthalmology & Visual Science, vol. 46, no. 6, pp. 1934–1939, 2005. View at Publisher · View at Google Scholar
  38. U. Hopfer, N. Fukai, H. Hopfer et al., “Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye,” The FASEB Journal, vol. 19, no. 10, pp. 1232–1244, 2005. View at Publisher · View at Google Scholar
  39. G. Ravalico, D. Tognetto, M. Palomba, S. Calderini, and O. Vattovani, “Corneal endothelial function in diabetes: a fluorophotometric study,” Ophthalmologica, vol. 208, no. 4, pp. 179–184, 1994. View at Google Scholar
  40. L.-I. Larsson, W. M. Bourne, J. M. Pach, and R. F. Brubaker, “Structure and function of the corneal endothelium in diabetes mellitus type I and type II,” Archives of Ophthalmology, vol. 114, no. 1, pp. 9–14, 1996. View at Google Scholar
  41. N. A. McNamara, R. J. Brand, K. A. Polse, and W. M. Bourne, “Corneal function during normal and high serum glucose levels in diabetes,” Investigative Ophthalmology & Visual Science, vol. 39, no. 1, pp. 3–17, 1998. View at Google Scholar
  42. M. Ziadi, P. Moiroux, P. d'Athis, A. Bron, J.-M. Brun, and C. Creuzot-Garcher, “Assessment of induced corneal hypoxia in diabetic patients,” Cornea, vol. 21, no. 5, pp. 453–457, 2002. View at Publisher · View at Google Scholar
  43. P. Cisarik-Fredenburg, “Discoveries in research on diabetic keratopathy,” Optometry, vol. 72, no. 11, pp. 691–704, 2001. View at Google Scholar
  44. Y. Kaji, S. Amano, T. Usui et al., “Advanced glycation end products in Descemet's membrane and their effect on corneal endothelial cell,” Current Eye Research, vol. 23, no. 6, pp. 469–477, 2001. View at Publisher · View at Google Scholar