Journal of Diabetes Research / 2009 / Article / Tab 3

Research Article

Influence of Overt Diabetes Mellitus on Cyclosporine Pharmacokinetics in a Canine Model

Table 3

Noncompartmental pharmacokinetic parameters of cyclosporine following an intravenous administration of 5 mg/kg in healthy and diabetic beagle dogs.

ParameterEstimate (Mean ± SEM)
Healthy dogDiabetic dog value

( g L-1)3680.50 ± 661.583721.28 ± 638.62.8801
MRT (hr)25.73 ± 3.0410.6313 ± 2.35.0098
( hr L-1)15892.66 ± 1225.4910144.39 ± 1113.72.0119
( hr L-1)25181.39 ± 1513.6312110.47 ± 1881.94.0019
CL (L hr-1 kg-1)0.201 ± 0.0100.457 ± 0.076.0019
(L Kg-1)5.12 ± 0.574.19 ± 0.45.2468
(hr-1)0.032 ± 0.0030.106 ± 0.037.0125
(hr)22.56 ± 2.30429.3194 ± 2.2896.0125

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