Journal of Diabetes Research / 2009 / Article / Fig 6

Research Article

Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat

Figure 6

Contraction-induced PTEN (Ser380/Thr382/383) phosphorylation is altered with insulin resistance. The basal (control) and contraction-induced phosphorylation of the GSK-3 in Plantaris and soleus muscles from lean (LNZ) and obese Zucker (OSXZ) rats at 0-, 1-, and 3-hours after HFES. Phosphorylation of PTEN was determined by immunodetection of phosphorylation on Ser380/Thr382/383. Relative abundance represents ratio of phosphor to total protein. An asterisk ( ) indicates significant difference (P < .05) from the control time point within animal model, and a cross ( ) indicates significant difference (P < .05) at corresponding time points across animal models.

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