Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat

<table>Contraction-induced PTEN (Ser380/Thr382/383) phosphorylation is altered with insulin resistance. The basal (control) and contraction-induced phosphorylation of the GSK-3<svg height="16.6625" id="M36" style="vertical-align:-3.56265pt" version="1.1" viewbox="0 0 10 16.6625" width="10" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> in Plantaris and soleus muscles from lean (LNZ) and obese Zucker (OSXZ) rats at 0-, 1-, and 3-hours after HFES. Phosphorylation of PTEN was determined by immunodetection of phosphorylation on Ser380/Thr382/383. Relative abundance represents ratio of phosphor to total protein. An asterisk (<svg height="13.75" id="M37" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 7.7375002 13.75" width="7.7375002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) indicates significant difference (<i>P</i> &lt; .05) from the control time point within animal model, and a cross (<svg height="15.8875" id="M38" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 6.5749998 15.8875" width="6.5749998" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) indicates significant difference (<i>P</i> &lt; .05) at corresponding time points across animal models.</table>

Journal of Diabetes Research

fig6

Figure 6

Figure 6: Altered Regulation of Contraction-Induced Akt/mTOR/p70S6k Pathway Signaling in Skeletal Muscle of the Obese Zucker Rat 