The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes
Relaxation of aorta from nondiabetic and diabetic males (left panels) and females (right panels) to acetylcholine ((a) and (b)) and nitroprusside ((c) and (d)). Relaxation to acetylcholine and nitroprusside was similar in nondiabetic males and females. Relaxation to acetylcholine was impaired in male but not female diabetics. In contrast, relaxation to nitroprusside was increased in both male and female diabetics ( per group, * versus nondiabetic).