The Role of Rho Kinase in Sex-Dependent Vascular Dysfunction in Type 1 Diabetes
Contractions of aorta from nondiabetic and diabetic males and females to serotonin. Contractions to serotonin were greater in aorta from nondiabetic males (a) than females ((b) per group, ). Following development of diabetes, contractions to serotonin were increased in males ((a) ) but not females ((b) , * nondiabetic versus diabetic). In diabetic males and females inhibition of rho kinase with fasudil (10 M) reduced contractions to serotonin ((c) males, , (d) females, , † diabetic versus diabetic plus fasudil).