Therapeutics of Diabetes Mellitus: Focus on Insulin Analogues and Insulin Pumps

Table 1

Main characteristics of rapid and long-acting insulin analogues.

Analogue	Trade name/manufacturer	Onset (min)	Peak (hrs)	Duration (hrs)
Long-acting analogues
Glargine	Lantus/Sanofi-Aventis	4–6 hrs	No peak	>24 hrs
Detemir	Levemir/Novo Nordisk	4–6 hrs	8–10 hrs	∼17 hrs
Rapid-acting analogues
Lispro	Humalog/Eli Lilly	15–30 min	0.5–2.5 hrs	3–6.5 hrs
Aspart	Novorapid/Novo Nordisk	10–20 min	1–3 hrs	3–5 hrs
Glulisine	Apidra/Sanofi-Aventis	10–15 min	1–1.5 hrs	3–5 hrs