Peroxynitrite Mediates Diabetes-Induced Endothelial Dysfunction: Possible Role of Rho Kinase Activation
Figure 3
FeTPPs restored nitric oxide production and eNOS expression in diabetic rat vessels. (a) Diabetes significantly reduced NO formation in rat aortic homogenate as measured by NO analyzer. Cotreatment of diabetic animals with FeTPPs restored NO back to normal levels (n = 6 in each group). Values are expressed as means ± SEM, versus control. (b) Real-time PCR of eNOS expression from aortic endothelial homogenate showed that diabetes significantly decreased eNOS expression (~50%) of control level, and FeTPPs restored eNOS expression to 87% of basal level (n = 5 in each group). Values are expressed as means ± SEM, versus control.
