Modulation of the Cellular Expression of Circulating Advanced Glycation End-Product Receptors in Type 2 Diabetic Nephropathy

Figure 3

Flow cytometric analysis for the cell surface expression of (a) RAGE and (b) AGER-1 and intracellular levels of (c) AGE-R1 and (d) AGE-R3 on PBMCs of human control, diabetic (DM) and diabetic individuals with renal impairment (DM + RI). (e) Positive correlation between cell surface expression of AGE-R1 and Albumin Excretion Rate (AER), 𝑃=.0056. Empty bars: control, grey bars: diabetes, and black bars are diabetes with renal impairment (iGFR<90) groups. nd: not detected. *𝑃<.05 versus control, ^†𝑃<.05 versus DM, ^ξ𝑃<.0001 versus control (𝑛=5-10/group).

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