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Experimental Diabetes Research
Volume 2011, Article ID 173647, 6 pages
Research Article

Evaluation of Glycemic and Lipid Profile of Offspring of Diabetic Wistar Rats Treated with Malpighia emarginata Juice

1Medical School of Medicine of Marília (UNIMAR), Faculty of Technology and Foods of Marília, Avenida Higino Muzzi Filho, 1001, Marília, SP 17525902, Brazil
2Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, UNESP, Distrito Rubião Junior, S/N, Botucatu, SP 18618000, Brazil
3Biochemistry Department, Faculty at UNINOVE and SENAC, USP/São Paulo, SP 01041000, Brazil
4Nutrition Department, Methodist University of Piracicaba, UNIMEP, Rua Tenente Florencio Pupo Neto, 300, Lins, SP 16400680, Brazil
5Nutrition Department, Frigorificos Bertin S/A, Rodovia de Acesso Lins-Getulina s/n, Parque Industrial, Lins, SP 16400000, Brazil
6Faculty of Technology and Foods of Marília, FATEC, Avenida Castro Alves, 62, Marília, SP 17506000, Brazil

Received 10 August 2010; Revised 6 December 2010; Accepted 3 January 2011

Academic Editor: I. Raz

Copyright © 2011 Sandra M. Barbalho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Knowing that maternal diabetes is related to hyperglycemia and fetal hyperinsulinemia, which affect the lipid metabolism, the aim of this study was to evaluate the effects of Malpighia emarginata (acerola) juice on the glycemic and lipid profile of offspring of diabetic and nondiabetic Wistar rats. The adult offspring of non-diabetic dams and of dams with severe streptozotocin-induced diabetes were divided into groups: G1, offspring (of control dams) treated with water, G2, offspring (of diabetic dams) treated with water, G3, male offspring (of control dams) treated with acerola juice, and G4, male offspring (of diabetic dams) treated with acerola juice. The offspring of diabetic dams treated with acerola juice showed significantly decreased levels of glucose, cholesterol, triglycerides, and increased HDL-c. The use of acerola juice is a potential strategy to aid in the prevention of DM and dyslipidemia and its complications or to act as an auxiliary in the treatment of these diseases.