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Experimental Diabetes Research
Volume 2011, Article ID 346051, 5 pages
Research Article

Increased Serum Levels of Uric Acid Are Associated with Sudomotor Dysfunction in Subjects with Type 2 Diabetes Mellitus

1Outpatient Clinic of Obesity, Diabetes, and Metabolism, Second Department of Internal Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece
2Department of Clinical Biochemistry, Vascular Disease Prevention Clinics, Royal Free Hospital, University College London Medical School, University College London (UCL), London NW3 2QG, UK
3Biochemistry Laboratory, University Hospital of Alexandroupolis, 68100 Alexandroupolis, Greece

Received 17 April 2011; Revised 27 June 2011; Accepted 12 July 2011

Academic Editor: Alexander Kokkinos

Copyright © 2011 N. Papanas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this paper was to assess serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM) with or without sudomotor dysfunction (evaluated by the Neuropad test). We included 36 T2DM patients with sudomotor dysfunction (group A: mean age years) and 40 age-, gender-, renal function- and T2DM duration-matched patients without sudomotor dysfunction (group B: mean age years). SUA was significantly higher in group A ( ). There was a significant correlation between SUA and Neuropad time to colour change in both groups (group A: , ; group B: , ). There was also a significant positive correlation between SUA and CRP in both groups (group A: , ; group B: , ). In conclusion, SUA levels were higher in T2DM patients with sudomotor dysfunction than those without this complication. The potential role of SUA in sudomotor dysfunction merits further study.