Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice

Figure 5

Insulin content per islet. (a) Exercise significantly improved the insulin content per islet between the two diabetic groups (𝑃<0.05). (b) Immunohistochemical staining showing the intensity of insulin-immunoreactive (red) cells in islets from pancreatic sections. (Scale bar: 50 μm.) (c) Quantification of the intensity of insulin-positive staining per islet in pancreatic sections. Exercise improved the total insulin staining intensity per islet significantly (**𝑃<0.001). (d) The intensity of insulin-positive staining was calculated per β-cell, and exercise significantly improved the insulin content per cell (**𝑃<0.001). Control 𝑁=76; sedentary diabetic 𝑁=43; exercised diabetic 𝑁=56.

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