Maternal Manganese Restriction Increases Susceptibility to High-Fat Diet-Induced Dyslipidemia and Altered Adipose Function in WNIN Male Rat Offspring

Table 6

Plasma adipocytokines status in offspring at 18 months of age.

		Normal-fat-fed offspring
	MnC	MnR	MnRC	MnRP	MnRW
MCP-1 (pg/mL)	174±51.4	197±88.9	811±555	78.9±4.69	255±131
Leptin (pg/mL)	2727±705	2226±391	2553±708	3279±1445	2399±533
IL-1β (pg/mL)	31.5±9.14	78.9±27.9	84.3±48.2	27.3±10.5	30.6±9.15
IL-6 (pg/mL)	12.9±0.036	35.3±11.2	68.6±32.5	33.6±0.69	24.5±6.47
TNF-α (pg/mL)	1.62±0.380^a	𝟏𝟔.𝟑±𝟎.𝟖𝟖𝟎^b	𝟏𝟑.𝟎±𝟎.𝟎𝟐𝟑^b	2.33±0.330^a	𝟏𝟐.𝟑±𝟎.𝟑𝟑𝟎^b
High-fat-fed offspring
	MnC	MnR	MnRC	MnRP	MnRW
MCP-1 (pg/mL)	36.3±0.850^a	𝟓𝟒.𝟏±𝟐.𝟎𝟕^b	𝟗𝟖.𝟖±𝟏.𝟑𝟒^c	𝟓𝟏.𝟎±𝟎.𝟔𝟒𝟎^b	𝟏𝟏𝟗±𝟑𝟎.𝟗^c
Leptin (pg/mL)	2344±315^a	𝟒𝟕𝟒𝟐±𝟏𝟔𝟒^b	3315±603^a	1898±956^a	2376±1028^a
IL-1β (pg/mL)	44.9±9.54^a	𝟏𝟑.𝟑±𝟏.𝟗𝟔^b	𝟐𝟒.𝟖±𝟐.𝟕𝟖^b,c	𝟐𝟑.𝟑±𝟔.𝟕𝟓^b	𝟗𝟒.𝟓±𝟑.𝟐𝟐^c
IL-6 (pg/mL)	20.9±0.580^a	𝟕𝟒.𝟒±𝟏.𝟖𝟎^b	𝟏𝟎.𝟕±𝟎.𝟔𝟓𝟎^c	𝟒𝟒.𝟔±𝟓.𝟖𝟖^c	𝟒𝟗.𝟗±𝟎.𝟓𝟕𝟎^c
TNF-α (pg/mL)	1.33±0.330^a	𝟒.𝟔𝟕±𝟎.𝟖𝟖𝟎^b	𝟐.𝟑𝟑±𝟎.𝟑𝟑𝟎^a,b	2.00±0.580^a	1.67±0.670^a

Values are mean ± SE (𝑛=6). Values bearing different superscript in a given row are significantly different from others by one-way ANOVA/multiple range test/least significant difference test. MnC: control group, MnR: manganese restricted group, MnRC: rehabilitation from conception group, MnRP: rehabilitation from parturition group, and MnRW: rehabilitation from weaning group. a,b and c: means without a common superscript are significantly different by One way ANOVA. b: 𝑃<0.01 and c: 𝑃<0.001.