Research Article

Assessment of Glucagon-Like Peptide-1 Analogue and Renin Inhibitor on the Binding and Regulation of GLP-1 Receptor in Type 1 Diabetic Rat Hearts

Table 1

The calculated dissociation constants ( ) and binding affinity constants ( ) of glucagon-like peptide-1 (GLP-1) with its receptor at the coronary endothelium (N = 8).

Rat Group (moles × 10-15) (min)

Normal (N)0.069 ± 0.005a
Diabetic (D)0.700 ± 0.029b
Diabetic + Insulin (DI)0.110 ± 0.025c
Diabetic + Exendin-4 (DE)0.580 ± 0.029d
Diabetic +Aliskiren (DA)0.857 ± 0.043e
Diabetic + Exendin-4
+ Aliskiren (DEA)
0.230 ± 0.039f
Diabetic + Insulin
+ Aliskiren (DIA)
0.650 ± 0.068g

Coronary endothelium: dissociation constants significant at for (a, f), (b, d), (b, e), (c, f) and for (a, b), (a, d), (a, e),(a, g), (b, c), (b, f), (c, d), (c, e), (c, g), (d, e), (d, f), (e, f), (f, g). The other comparative values are not significant ( ). Binding affinities significant at for (c′, f′) and for (a′, b′), (a′, c′), (a′, d′), (a′, e′), (a′, g′), (b′, c′), (b′, d′), (b′, f′), (b′, g′), (c′, d′), (c′, e′), (c′, g′), (d′, e′), (d′, f′), (d′, g′), (e′, f′), (e′, g′), (f′, g′). The other comparative values are not significant ( ).