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Experimental Diabetes Research
Volume 2011, Article ID 498460, 10 pages
http://dx.doi.org/10.1155/2011/498460
Research Article

Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus

1Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan
2CNV Laboratory, DNA Chip Research Institute, 1-1-43 Suehiro-cho, Tsurumi-ku Yokohama, Kanagawa 230-0045, Japan
3Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan

Received 6 October 2010; Revised 21 February 2011; Accepted 30 March 2011

Academic Editor: Kazuya Yamagata

Copyright © 2011 Hirohito Kudo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The supplementary materials provided characteristics of subjects in the first whole‐genome CNV analysis (Table S1), characteristics of subjects with and without copy number losses at 4p16.3 subteromeric region (Table S2), characteristics of subjects with and without copy number losses at 4p16.3 subteromeric resion (Table S3), raw data of log2 ratio measured at each probe on chromosome 4p at screening step via deCODE/Illumina beads chip (Table S4), and raw data of log2 ratio measured at each probe by high-density custom-made tilling array analysis (Table S5).

  1. Supplementary Material