Table of Contents Author Guidelines Submit a Manuscript
Experimental Diabetes Research
Volume 2011, Article ID 623472, 8 pages
http://dx.doi.org/10.1155/2011/623472
Research Article

Altered Expression of Somatostatin Receptors in Pancreatic Islets from NOD Mice Cultured at Different Glucose Concentrations In Vitro and in Islets Transplanted to Diabetic NOD Mice In Vivo

1Department of Medical Cell Biology, Uppsala University, Biomedicum, P.O. Box 571, 75123 Uppsala, Sweden
2Section of Clinical Chemistry, Department of Medical Sciences, University Hospital, Uppsala University, 75185 Uppsala, Sweden
3Section of Endocrine Oncology, Department of Medical Sciences, University Hospital, Uppsala University, 75185 Uppsala, Sweden

Received 11 April 2011; Accepted 2 July 2011

Academic Editor: Francesco Chiarelli

Copyright © 2011 Eva Ludvigsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Ludvigsen, M. Stridsberg, E. T. Janson, and S. Sandler, “Expression of somatostatin receptor subtypes 1-5 in pancreatic islets of normoglycaemic and diabetic NOD mice,” European Journal of Endocrinology, vol. 153, no. 3, pp. 445–454, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L. N. Møller, C. E. Stidsen, B. Hartmann, and J. J. Holst, “Somatostatin receptors,” Biochimica et Biophysica Acta, vol. 1616, no. 1, pp. 1–84, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. C. Patel, “Somatostatin and its receptor family,” Frontiers in Neuroendocrinology, vol. 20, no. 3, pp. 157–198, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. I. Shimon, J. E. Taylor, J. Z. Dong et al., “Somatostatin receptor subtype specificity in human fetal pituitary cultures. Differential role of SSTR2 and SSTR5 for growth hormone, thyroid- stimulating hormone, and prolactin regulation,” Journal of Clinical Investigation, vol. 99, no. 4, pp. 789–798, 1997. View at Google Scholar · View at Scopus
  5. M. C. Zatelli, D. Piccin, F. Tagliati et al., “Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 6, pp. 2797–2802, 2003. View at Google Scholar · View at Scopus
  6. B. Hunyady, R. W. Hipkin, A. Schonbrunn, and A. Mezey, “Immunohistochemical localization of somatostatin receptor SST2A in the rat pancreas,” Endocrinology, vol. 138, no. 6, pp. 2632–2635, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Ludvigsen, R. Olsson, M. Stridsberg, E. T. Janson, and S. Sandler, “Expression and distribution of somatostatin receptor subtypes in the pancreatic islets of mice and rats,” Journal of Histochemistry and Cytochemistry, vol. 52, no. 3, pp. 391–400, 2004. View at Google Scholar · View at Scopus
  8. S. W. Mitra, E. Mezey, B. Hunyady et al., “Colocalization of somatostatin receptor sst5 and insulin in rat pancreatic β-cells,” Endocrinology, vol. 53, no. 8, pp. 3790–3796, 1999. View at Google Scholar · View at Scopus
  9. M. A. Atkinson and E. H. Leiter, “The NOD mouse model of type 1 diabetes: as good as it gets?” Nature Medicine, vol. 5, no. 6, pp. 601–604, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Sandler, A. Andersson, and C. Hellerstrom, “Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets,” Endocrinology, vol. 121, no. 4, pp. 1424–1431, 1987. View at Google Scholar · View at Scopus
  11. S. Sandler, K. Bendtzen, D. L. Eizirik, E. Strandell, M. Welsh, and N. Welsh, “Metabolism and β-cell function of rat pancreatic islets exposed to human interleukin-1β in the presence of a high glucose concentration,” Immunology Letters, vol. 26, no. 3, pp. 245–251, 1990. View at Publisher · View at Google Scholar · View at Scopus
  12. G. M. Portela-Gomes, M. Stridsberg, L. Grimelius, K. Öberg, and E. T. Janson, “Expression of the five different somatostatin receptor subtypes in endocrine cells of the pancreas,” Applied Immunohistochemistry and Molecular Morphology, vol. 8, no. 2, pp. 126–132, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. I. N. Nomikos, S. J. Prowse, P. Carotenuto, and K. J. Lafferty, “Combined treatment with nicotinamide and desferrioxamine prevents islet allograft destruction in NOD mice,” Diabetes, vol. 35, no. 11, pp. 1302–1304, 1986. View at Google Scholar · View at Scopus
  14. A. E. Panerai, F. Nicoletti, P. Sacedote et al., “MFP14, a multifunctional emerging protein with immunomodulatory properties, prevents spontaneous and recurrent autoimmune diabetes in NOD mice,” Diabetologia, vol. 44, no. 7, pp. 839–847, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Ludvigsen, M. Stridsberg, J. E. Taylor et al., “Regulation of insulin and glucagon secretion from rat pancreatic islets in vitro by somatostatin analogues,” Regulatory Peptides, vol. 138, no. 1, pp. 1–9, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Z. Strowski, R. M. Parmar, A. D. Blake, and J. M. Schaeffer, “Somatostatin inhibits insulin and glucagon secretion via two receptor subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice,” Endocrinology, vol. 141, no. 1, pp. 111–117, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Z. Strowski, M. Kohler, H. Y. Chen et al., “Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis,” Molecular Endocrinology, vol. 17, no. 1, pp. 93–106, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Yoshitomi, Y. Fujii, M. Miyazaki, N. Nakajima, N. Inagaki, and S. Seino, “Involvement of MAP kinase and c-fos signaling in the inhibition of cell growth by somatostatin,” American Journal of Physiology, vol. 272, no. 5, pp. E769–E774, 1997. View at Google Scholar · View at Scopus
  19. B. Furman, N. Pyne, P. Flatt, and F. O'Harte, “Targeting β-cell cyclic 3′5′ adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A rewiew,” Journal of Pharmacy and Pharmacology, vol. 56, no. 12, pp. 1477–1492, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. T. E. Adrian, S. R. Bloom, and M. G. Bryant, “Distribution and release of human pancreatic polypeptide,” Gut, vol. 17, no. 12, pp. 940–944, 1976. View at Google Scholar · View at Scopus