Neurovascular Interaction and the Pathophysiology of Diabetic Retinopathy
Figure 2
Membrane current response elicited from an isolated rat retinal bipolar cell by 5-methyl-I4AA (100 μM) in normal saline (control), when coapplied with 100 μM bicuculline, a GABAA receptor antagonist (Bic.), or coapplied with 250 μM TPMPA, a GABAC receptor antagonist (TPMPA). Note that bicuculline has a negligible effect on the 5-methyl-I4AA-induced current, whereas TPMPA suppresses the response almost completely. Both actions confirm that there are few or no GABAA receptors involved in 5-methyl-I4AA response elicited from rat bipolar cells.
