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Experimental Diabetes Research
Volume 2011, Article ID 906154, 6 pages
Research Article

Obesity and Blood Pressure in 17-Year-Old Offspring of Mothers with Gestational Diabetes: Insights from the Jerusalem Perinatal Study

1Epidemiology Unit, Hebrew University Braun School of Public Health, P.O. Box 12272, Jerusalem 91120, Israel
2Department of Human Genetics, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel
3Department of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA
4Obstetric and Gynecology Department, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel

Received 8 February 2011; Revised 6 April 2011; Accepted 24 May 2011

Academic Editor: Barbara Alexander

Copyright © 2011 Meytal Avgil Tsadok et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. Gestational diabetes mellitus (GDM) influences fetal development and offspring's metabolic risk. We evaluated this association in 17-year-old offspring adjusting for birth weight (BW) and prepregnancy maternal BMI (mBMI). Study Design. The JPS birth cohort contains extensive data on 92,408 births from 1964 to 1976. Offspring's BMI and blood pressure (BP) were obtained from military records. For a subcohort born between 1974 and 1976, prepregnancy mBMI was available. Offspring were classified as born to mothers with GDM ( 𝑛 = 2 9 3 ) or born to mothers without recorded GDM ( 𝑛 = 5 9 , 4 9 9 ). Results. GDM offspring had higher mean BMI and systolic and diastolic BP compared to no-recorded-GDM offspring. After adjusting for BW, GDM remained significantly associated with offspring BMI and diastolic BP ( 𝛽 = 1.169 and 1.520, resp.). In the subcohort, when prepregnancy mBMI was entered to the models, it markedly attenuated the associations with GDM. Conclusions. Maternal characteristics have long-term effects on cardiometabolic outcomes of their offspring aged 17 years.